E-Cadherin*

Protein E-Cadherin* map

Identifiers
cadherin 1, type 1, E-cadherin (epithelial)
HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1
UVO

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / ADHERENS_JUNCTIONS  map
 DNA repair  map  / M_CC_PHASE  map
 Survival  map  / WNT_CANONICAL  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:10671552
PMID:11348595
PMID:17928543
in vitro phosphorylation of Cadherin at S834, 836, 842 significantly enhances the affinity with which beta-catenin binds cadherins.
GSK3B and CSNK2 (casein kinase II) have been shown to phosphorylate these sites in vitro.
PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786
PMID:19029934
PMID:22007144

E-Cadherin*@Cytoplasm

References
e_re1007( EMT  map ):
PMID:10671552
PMID:11348595
PMID:17928543
in vitro phosphorylation of Cadherin at S834, 836, 842 significantly enhances the affinity with which beta-catenin binds cadherins.
GSK3B and CSNK2 (casein kinase II) have been shown to phosphorylate these sites in vitro.
e_re1008( EMT  map ):
PMID:17353278
Phosphorylation of E-cadherin at S846 by casein kinase I decreases its ability to bind to CTNNB1.
e_re1632( EMT  map ):
PMID:16371504
N-cadherin is phosphorylated by c-Src at Tyr-820, Tyr-853, Tyr-860, Tyr-884, and Tyr-886.
Phosphorylation of Tyr-860 (Tyr-835 in E-cadherin) can disrupt cadherin binding to beta-catenin

E-Cadherin*|​hm2@Cytoplasm

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / ADHERENS_JUNCTIONS  map

References
PMID:11413131
E-cadherin dimerization is essential for adhesion to the integrin aEb7
PMID:17325197
Interaction between E-cadherin and aEb7 integrin plays major role in effective tumor cell lysis, during cytolytic granule polarization and subsequent exocytosis

E-Cadherin*|​hm2@Extracellular space

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / ADHERENS_JUNCTIONS  map

References
PMID:11413131
E-cadherin dimerization is essential for adhesion to the integrin aEb7
PMID:17325197
Interaction between E-cadherin and aEb7 integrin plays major role in effective tumor cell lysis, during cytolytic granule polarization and subsequent exocytosis

E-Cadherin*|​S_pho@Cytoplasm

References
e_re1007( EMT  map ):
PMID:10671552
PMID:11348595
PMID:17928543
in vitro phosphorylation of Cadherin at S834, 836, 842 significantly enhances the affinity with which beta-catenin binds cadherins.
GSK3B and CSNK2 (casein kinase II) have been shown to phosphorylate these sites in vitro.
e_re1008( EMT  map ):
PMID:17353278
Phosphorylation of E-cadherin at S846 by casein kinase I decreases its ability to bind to CTNNB1.

E-Cadherin*|​hm2@Cytoplasm

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / ECM  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / ADHERENS_JUNCTIONS  map

References
PMID:11413131
E-cadherin dimerization is essential for adhesion to the integrin aEb7
PMID:17325197
Interaction between E-cadherin and aEb7 integrin plays major role in effective tumor cell lysis, during cytolytic granule polarization and subsequent exocytosis

E-Cadherin*|​Y_pho@Cytoplasm

References
e_re1632( EMT  map ):
PMID:16371504
N-cadherin is phosphorylated by c-Src at Tyr-820, Tyr-853, Tyr-860, Tyr-884, and Tyr-886.
Phosphorylation of Tyr-860 (Tyr-835 in E-cadherin) can disrupt cadherin binding to beta-catenin

E-Cadherin*|​pho@Endosome

References
s_wca1_re42:( Survival  map ) PMID:21606194

E-Cadherin*|​S840_pho|​S853_pho|​S855_pho@Cytoplasm

Maps_Modules
 Survival  map  / WNT_CANONICAL  map

References
s_wca2_re53:( Survival  map ) PMID:10671551 PMID:10837139

E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho@Cytoplasm

Maps_Modules
 Survival  map  / WNT_CANONICAL  map

References
s_wca2_re54:( Survival  map ) PMID:10671551
s_wca2_re50:( Survival  map ) PMID:22659456 PMID:22007144 PMID:19171760 PMID:10931041
s_wca2_re67:( Survival  map ) PMID:22370635

E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho@Cytoplasm

Maps_Modules
 Survival  map  / WNT_CANONICAL  map


Modifications:
In compartment: Cytoplasm
  1. E-Cadherin*@Cytoplasm map

  2. E-Cadherin*|​hm2@Cytoplasm map
  3. E-Cadherin*|​hm2@Cytoplasm map
  4. E-Cadherin*|​S_pho@Cytoplasm map
  5. E-Cadherin*|​S_pho@Cytoplasm map
  6. E-Cadherin*|​Y_pho@Cytoplasm map
  7. E-Cadherin*|​S840_pho|​S853_pho|​S855_pho@Cytoplasm map
  8. E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho@Cytoplasm map
  9. E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho@Cytoplasm map

In compartment: Endosome

  1. E-Cadherin*|​pho@Endosome map

In compartment: Extracellular space

  1. E-Cadherin*@Extracellular space map

  2. E-Cadherin*|​hm2@Extracellular space map

In compartment: default

  1. E-Cadherin*@default map

Participates in complexes:
In compartment: Cytoplasm

  1. E-Cadherin*:​G_alpha_o*@Cytoplasm map

  2. E-Cadherin*:​G_alpha_o*@Cytoplasm map
  3. Cytoskeleton:​E-Cadherin*@Cytoplasm map
  4. E-Cadherin*:​cytoskeleton@Cytoplasm map
  5. CK1_epsilon_*:​E-Cadherin*@Cytoplasm map
  6. E-Cadherin*:​G_alpha__sub_12_endsub_*@Cytoplasm map
  7. E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​_beta_-Catenin*|​Y654_pho|​pho@Cytoplasm map
  8. CRIPTO-1*:​E-Cadherin*:​G_alpha_o*@Cytoplasm map
  9. E-Cadherin*|​hm2:​ITGAE:​ITGB7@Cytoplasm map
  10. Cytoskeleton:​E-Cadherin*:​_beta_-Catenin*|​Y142_pho@Cytoplasm map
  11. E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​TGFB1:​TGFBR*@Cytoplasm map
  12. Cytoskeleton:​E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ECM or cell-cell contact@Cytoplasm map
  13. CK1_epsilon_*:​E-Cadherin*:​LGR5:​RSPO1-4*@Cytoplasm map

In compartment: Endosome

  1. E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​p120*@Endosome map

  2. E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​pho:​p120*@Endosome map
  3. E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​Y654_pho|​pho:​p120*@Endosome map
  4. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  5. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  6. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  7. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  8. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome map
  9. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map

In compartment: Vaceolae

  1. CK1_epsilon_*:​E-Cadherin*:​LRP5_6*:​p120*@Vaceolae map

  2. CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​p120*@Vaceolae map
  3. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map
  4. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map

In compartment: default

  1. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*@default map

  2. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*|​pho@default map

Participates in reactions:
As Reactant or Product:

  1. E-Cadherin*@default map + APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*@default map map APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*@default map

  2. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*@default map map APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*|​pho@default map
  3. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*|​pho@default map map APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*@default map
  4. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*@default map map E-Cadherin*@default map + APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*@default map
  5. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*@default map map M phase exit@default map
  6. E-Cadherin*@Cytoplasm map map E-Cadherin*|​S_pho@Cytoplasm map
  7. E-Cadherin*@Cytoplasm map map E-Cadherin*|​S_pho@Cytoplasm map
  8. E-Cadherin*@Extracellular space map + E-Cadherin*@Cytoplasm map map E-Cadherin*|​hm2@Cytoplasm map
  9. Plakoglobin binding partners*@Cytoplasm map map E-Cadherin*@Cytoplasm map
  10. Cadherin*@Cytoplasm map map E-Cadherin*@Cytoplasm map
  11. E-Cadherin*|​Y_pho@Cytoplasm map map degraded
  12. Cadherin*@Cytoplasm map map E-Cadherin*|​S_pho@Cytoplasm map
  13. Cadherin*@Cytoplasm map map E-Cadherin*|​S_pho@Cytoplasm map
  14. E-Cadherin*@Cytoplasm map map E-Cadherin*|​Y_pho@Cytoplasm map
  15. rE-Cadherin*@Nucleus map map E-Cadherin*@Cytoplasm map
  16. E-Cadherin*|​hm2@Cytoplasm map + ITGAE:​ITGB7@Cytoplasm map map E-Cadherin*|​hm2:​ITGAE:​ITGB7@Cytoplasm map
  17. E-Cadherin*|​hm2:​ITGAE:​ITGB7@Cytoplasm map map Exocytosis@Extracellular space map
  18. E-Cadherin*@Cytoplasm map map E-Cadherin*|​hm2@Cytoplasm map
  19. E-Cadherin*@Extracellular space map map E-Cadherin*|​hm2@Extracellular space map
  20. E-Cadherin*|​hm2@Cytoplasm map map Adherens junctions@Cytoplasm map
  21. WNT*@default map + CK1_epsilon_*:​E-Cadherin*:​LRP5_6*:​p120*@Vaceolae map + s_s_wca1_s211 + GTP@Vaceolae map + PRR*@Cytoplasm map map CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​p120*@Vaceolae map + GDP@Vaceolae map
  22. DVL*|​pho|​S139_emp|​S142_emp:​_beta_-Arrestin2*@Cytoplasm map + CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​p120*@Vaceolae map + AMER1*:​CK1_gamma_*:​PtdIns(4,5)-P2@Cytoplasm map map AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map + s_s_wca1_s1187 + G_beta_*:​G_gamma_*@Cytoplasm map
  23. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map map AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map
  24. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm map map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  25. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  26. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm map map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  27. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map map AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  28. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  29. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome map
  30. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome map map CK1_epsilon_*:​p120*|​S268_pho|​S269_pho@Endosome map + E-Cadherin*|​pho@Endosome map + AMER1*:​AXIN*:​CK1_alpha_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map
  31. E-Cadherin*|​pho@Endosome map map Recycling @Cytoplasm map
  32. E-Cadherin*|​pho@Endosome map map Degradation@Cytoplasm map
  33. E-Cadherin*:​G_alpha_o*@Cytoplasm map map LRP5_6*@Cytoplasm map + E-Cadherin*:​G_alpha_o*@Cytoplasm map
  34. LRP5_6*@Cytoplasm map map E-Cadherin*:​G_alpha_o*@Cytoplasm map
  35. Cytoskeleton:​E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ECM or cell-cell contact@Cytoplasm map + TGFB1:​TGFBR*@Cytoplasm map map E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​TGFB1:​TGFBR*@Cytoplasm map + ECM or cell-cell contact@default map
  36. E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​TGFB1:​TGFBR*@Cytoplasm map map E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​pho:​p120*@Endosome map
  37. E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​pho:​p120*@Endosome map map E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​Y654_pho|​pho:​p120*@Endosome map
  38. E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​_beta_-Catenin*|​Y654_pho|​pho:​p120*@Endosome map map E-Cadherin*:​ITGA3:​TGFB1:​TGFBR*:​p120*@Endosome map + _beta_-Catenin*|​Y654_pho@Cytoplasm map
  39. E-Cadherin*:​G_alpha_o*@Cytoplasm map map WNT canonical pathway@Cytoplasm map
  40. ECM or cell-cell contact@default map + E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho@Cytoplasm map + p120*@Cytoplasm map + ITGA3@Cytoplasm map + Cytoskeleton@Cytoplasm map + _alpha_-Catenin*@Cytoplasm map + _beta_-Catenin*|​pho@Cytoplasm map map Cytoskeleton:​E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​ECM or cell-cell contact@Cytoplasm map
  41. E-Cadherin*@Cytoplasm map map E-Cadherin*|​S840_pho|​S853_pho|​S855_pho@Cytoplasm map
  42. E-Cadherin*|​S840_pho|​S853_pho|​S855_pho@Cytoplasm map map E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho@Cytoplasm map
  43. ITGA9@Cytoplasm map + _beta_-Catenin*|​pho@Cytoplasm map + E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho@Cytoplasm map map s_s_wca2_s265
  44. s_s_wca2_s265 map E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​_beta_-Catenin*|​Y654_pho|​pho@Cytoplasm map
  45. E-Cadherin*|​S840_pho|​S853_pho|​S855_pho|​S849_pho:​_beta_-Catenin*|​Y654_pho|​pho@Cytoplasm map map s_s_wca2_s280 + _beta_-Catenin*|​Y654_pho@Cytoplasm map
  46. CRIPTO-1*:​E-Cadherin*:​G_alpha_o*@Cytoplasm map map WNT canonical pathway@Cytoplasm map
  47. E-Cadherin*:​G_alpha_o*@Cytoplasm map + s_s_wca2_s284 map CRIPTO-1*:​E-Cadherin*:​G_alpha_o*@Cytoplasm map
  48. LGR5:​RSPO1-4*@Cytoplasm map + CK1_epsilon_*:​E-Cadherin*@Cytoplasm map map CK1_epsilon_*:​E-Cadherin*:​LGR5:​RSPO1-4*@Cytoplasm map
  49. CK1_epsilon_*:​E-Cadherin*:​LGR5:​RSPO1-4*@Cytoplasm map map WNT canonical pathway@Cytoplasm map
  50. E-Cadherin*@Cytoplasm map + p120*@Cytoplasm map + _alpha_-Catenin*@Cytoplasm map + _beta_-Catenin*@Cytoplasm map + Cytoskeleton@Cytoplasm map map Cytoskeleton:​E-Cadherin*@Cytoplasm map
  51. E-Cadherin*@Cytoplasm map + G_alpha__sub_12_endsub_*@Cytoplasm map map E-Cadherin*:​G_alpha__sub_12_endsub_*@Cytoplasm map
  52. Cytoskeleton:​E-Cadherin*@Cytoplasm map map _beta_-Catenin*@Cytoplasm map + p120*@Cytoplasm map + E-Cadherin*@Cytoplasm map + _alpha_-Catenin*@Cytoplasm map
  53. Cytoskeleton:​E-Cadherin*@Cytoplasm map map Cytoskeleton:​E-Cadherin*:​_beta_-Catenin*|​Y142_pho@Cytoplasm map
  54. Cytoskeleton:​E-Cadherin*:​_beta_-Catenin*|​Y142_pho@Cytoplasm map map _beta_-Catenin*|​Y142_pho@Cytoplasm map + E-Cadherin*:​cytoskeleton@Cytoplasm map

As Catalyser:

  1. M phase@default map map G1 phase@default map

  2. CyclinA1*@default map map degraded
  3. CyclinB1*@default map map degraded
  4. CDC25A@default map map degraded
  5. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map map AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map
  6. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  7. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome map
  8. DVL*@Cytoplasm map + s_s_wca1_s725 map DVL*:​KLHL*@Cytoplasm map
  9. s_s_wca1_s758 map JBN*:​_beta_-Catenin*@Cilium map
  10. JBN*:​_beta_-Catenin*@Cilium map map s_s_wca1_s764
  11. ATP6V0C_D*@Vaceolae map map ATP6V0C_D*@Vaceolae map
  12. SRC@Cytoplasm map map SRC@Cytoplasm map
  13. Cytoskeleton:​E-Cadherin*@Cytoplasm map map _beta_-Catenin*@Cytoplasm map + p120*@Cytoplasm map + E-Cadherin*@Cytoplasm map + _alpha_-Catenin*@Cytoplasm map

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