DYRK1A

Protein DYRK1A map

Identifiers
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
HUGO:DYRK1A HGNC:3091 ENTREZ:1859 UNIPROT:Q13627 GENECARDS:DYRK1A REACTOME:54046 KEGG:1859 ATLASONC:DYRK1AID43234ch21q22 WIKI:DYRK1A
DYRK, DYRK1, MNBH

Maps_Modules
 Apoptosis  map  / CASPASES  map
 Survival  map  / HEDGEHOG  map
 Survival  map  / PI3K_AKT_MTOR  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:11980723
PMID:19685005
Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase

DYRK1A@Cytoplasm

References
a_re498( Apoptosis  map ):
PMID:12792650
Direct phosphorylation of CASP9 by ERK2 sufficient to block CASP9 processing
in vitro, recombinant hCASP9 phosphorylated on T125 by cytosolic extract or ERK2
in Hela cells, interaction GST-CASP9 / ERK
in Hela or HEK293, CASP9 T125 phosphorylation by OA, consititutively active MEK1, EGF or TPA
PMID:17466630
CASP9 T125 phosphorylation by CCNB1:CDC2
comment: phosphorylation during mitosis, when nuclear envelope is broken down
PMID:19081073
CASP9 T125 phosphorylation by DYRK1A
PMID:19016842
PMID:19586613
CASP9 T125 phosphorylation by DYRK1A and p38

DYRK1A@Nucleus

References
s_shh2_re7:( Survival  map ) PMID:12138125

DYRK1A@Nucleus

References
s_akt2_re122:( Survival  map ) PMID:11980723
s_wnc2_re56( Survival  map ):
DYRK1A/B primes NFAT in the nucleus, DYRK2 in the cytosol
PMID:16511445


Modifications:
In compartment: Cytoplasm
  1. DYRK1A@Cytoplasm map

In compartment: Nucleus

  1. DYRK1A@Nucleus map

  2. DYRK1A@Nucleus map
  3. DYRK1A@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

      As Catalyser:

      1. Caspase9*|​S196_unk|​S144_unk|​Y153_unk@Cytoplasm map map Caspase9*|​S196_unk|​T125_pho|​S144_unk|​Y153_unk@Cytoplasm map

      2. FOXO1|​T24_pho|​S322_pho|​S256_pho|​S319_pho|​S325_pho|​S329_emp@Nucleus map map FOXO1|​T24_pho|​S322_pho|​S256_pho|​S319_pho|​S325_pho|​S329_pho@Nucleus map
      3. gpromoter_region@Nucleus map + GLI1|​pho|​pho@Nucleus map map GLI1|​pho|​pho:​promoter_region@Nucleus map
      4. GLI1@Nucleus map map GLI1|​pho|​pho@Nucleus map
      5. NFAT*@Nucleus map map NFAT*|​pho|​pho@Nucleus map

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