DVL*

Protein DVL* map

Identifiers
dishevelled dsh homolog 1 (Drosophila)
HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1
dishevelled dsh homolog 2 (Drosophila)
HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2
dishevelled dsh homolog 3 (Drosophila)
HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3
“dishevelled 1 (homologous to Drosophila dsh)”

Maps_Modules
 Survival  map  / WNT_CANONICAL  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:20006983

DVL*@Cytoplasm

References
s_wca3_re167( Survival  map ):
Contains a NES
PMID:15720724
s_wca1_re26( Survival  map ):
PMID:16707567 PMID:21285348
DVL is primed by CK2 and/or MARK2
s_wca1_re51( Survival  map ):
PMID:16547521
In the presence of WNT3a DVL-3 forms complex with KLHL12/CUL3/RBX1-complex
s_wca1_re53:( Survival  map ) PMID:15852005
s_wca1_re79:( Survival  map ) PMID:11113207 PMID:18931698
s_wca3_re168( Survival  map ):
contains NLS import higher when stimulated with wnt3
s_wnc1_re15:( Survival  map ) PMID:20223821
s_wnc2_re3( Survival  map ):
Binding of Wnt5 and LRP5/6 leads to phosphorylation of Dvl. Most likely the same residues as picture shows same speed of migration on gel compared to Wnt3 stimulation. No phosphorylation of LRP5/6 by Wnt5. This complex formation sequesters away Wnt5 from the non-canonical pathway receptors
PMID:19056682
s_wnc4_re45:( Survival  map ) PMID:17588722
s_s_wca3_re168( Survival  map ):

DVL*|​pho|​S139_emp|​S142_emp@Cytoplasm

References
s_wca1_re26( Survival  map ):
PMID:16707567 PMID:21285348
DVL is primed by CK2 and/or MARK2
s_wca1_re29( Survival  map ):
PMID:19705439 PMID:17426148
Beta-ARRESTIN binds to phosphorylated DVL

DVL*@Nucleus

References
s_wca3_re168( Survival  map ):
contains NLS import higher when stimulated with wnt3
PMID:15720724
s_wca3_re139:( Survival  map ) PMID:19183803
s_wca3_re167( Survival  map ):
Contains a NES
s_wca3_re169( Survival  map ):
Upon WNT3a stimulation formation complex DVL with c-jun
PMID:18347071
s_s_wca3_re167( Survival  map ):

DVL*@Cytoplasm

References
s_wnc1_re65( Survival  map ):
Active PKC phosphorylates Dvl, just not enough to achieve the PS-form.
PMID:12958364
s_wnc1_re95:( Survival  map ) PMID:16446366

DVL*|​pho|​emp|​emp@Cytoplasm

References
s_wnc1_re15:( Survival  map ) PMID:20223821

DVL*|​pho|​pho|​pho@Cytoplasm

References
s_wnc1_re65( Survival  map ):
Active PKC phosphorylates Dvl, just not enough to achieve the PS-form.
PMID:12958364


Modifications:
In compartment: Cytoplasm
  1. DVL*@Cytoplasm map

  2. DVL*@Cytoplasm map
  3. DVL*@Cytoplasm map
  4. DVL*@Cytoplasm map
  5. DVL*@Cytoplasm map
  6. DVL*|​pho|​emp|​emp@Cytoplasm map
  7. DVL*|​pho|​pho|​pho@Cytoplasm map
  8. DVL*|​pho|​S139_emp|​S142_emp@Cytoplasm map
  9. DVL*|​pho|​emp|​emp|​ubi@Cytoplasm map

In compartment: Endosome

  1. DVL*|​pho|​S139_pho|​S142_pho|​pho@Endosome map

In compartment: Nucleus

  1. DVL*@Nucleus map

Participates in complexes:
In compartment: Cilium

  1. DVL*:​Iversin*@Cilium map

In compartment: Cytoplasm

  1. DACT1:​DVL*@Cytoplasm map

  2. DVL*:​IDAX*@Cytoplasm map
  3. DVL*:​KLHL*@Cytoplasm map
  4. DVL*:​Iversin*@Cytoplasm map
  5. DVL*|​pho|​emp|​emp:​_beta_-Arrestin2*@Cytoplasm map
  6. DVL*|​pho|​S139_emp|​S142_emp:​_beta_-Arrestin2*@Cytoplasm map
  7. DVL*|​pho:​G_alpha__sub_13q_endsub_*:​_beta_-Arrestin*@Cytoplasm map
  8. DVL*|​pho:​G_alpha__sub_13q_endsub_*:​_beta_-Arrestin*@Cytoplasm map
  9. AXIN*:​DVL*:​HSC70*:​HTID1_50_48_kDa_isoform*@Cytoplasm map
  10. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​ROR2|​S864_emp|​emp|​emp:​SYN4*:​VANGL*|​emp|​emp|​emp|​emp:​_beta_-Arrestin2*@Cytoplasm map
  11. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRR*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map
  12. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map
  13. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map
  14. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho|​ubi:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map
  15. APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​pho|​pho:​GSK3*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​_beta_-Arrestin2*@Cytoplasm map
  16. APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​pho|​pho:​GSK3*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​_beta_-Arrestin2*@Cytoplasm map

In compartment: Endosome

  1. AMER1*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho|​pho:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map

  2. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  3. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  4. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  5. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​FZD*:​PAR6*:​PRR*:​RAC1:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  6. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  7. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  8. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map
  9. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WNT*:​_beta_-Arrestin2*@Endosome map
  10. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  11. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  12. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  13. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  14. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome map
  15. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map

In compartment: Nucleus

  1. DVL*:​HIPK1@Nucleus map

  2. DVL*:​JUN|​pho|​pho@Nucleus map
  3. BCL9:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map
  4. BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus map
  5. BCL9:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map
  6. BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_emp|​ace|​ace@Nucleus map
  7. APC|​T1487_pho:​BCL9:​CTBP*|​hm2:​DVL*:​HDAC1_2*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map

In compartment: Vaceolae

  1. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map

  2. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map

Participates in reactions:
As Reactant or Product:

  1. DVL*@Cytoplasm map map DVL*|​pho|​S139_emp|​S142_emp@Cytoplasm map

  2. DVL*|​pho|​S139_emp|​S142_emp:​_beta_-Arrestin2*@Cytoplasm map + CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​p120*@Vaceolae map + AMER1*:​CK1_gamma_*:​PtdIns(4,5)-P2@Cytoplasm map map AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map + s_s_wca1_s1187 + G_beta_*:​G_gamma_*@Cytoplasm map
  3. DVL*|​pho|​S139_emp|​S142_emp@Cytoplasm map + G_beta_*:​G_gamma_*@Cytoplasm map + _beta_-Arrestin2*@Cytoplasm map map DVL*|​pho|​S139_emp|​S142_emp:​_beta_-Arrestin2*@Cytoplasm map
  4. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map map AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map
  5. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm map map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  6. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  7. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm map map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  8. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map map AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  9. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  10. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome map
  11. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome map map CK1_epsilon_*:​p120*|​S268_pho|​S269_pho@Endosome map + E-Cadherin*|​pho@Endosome map + AMER1*:​AXIN*:​CK1_alpha_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map
  12. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map map AMER1*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho|​pho:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Endosome map
  13. DVL*@Cytoplasm map + s_s_wca1_s725 map DVL*:​KLHL*@Cytoplasm map
  14. DVL*@Cytoplasm map + Iversin*@Cytoplasm map map DVL*:​Iversin*@Cytoplasm map
  15. DVL*:​Iversin*@Cytoplasm map map DVL*:​Iversin*@Cilium map
  16. AMER1*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho|​pho:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map map Recycling @Cytoplasm map
  17. AMER1*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho|​pho:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map map Degradation@Cytoplasm map
  18. AMER1*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho|​pho:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map map DVL*|​pho|​S139_pho|​S142_pho|​pho@Endosome map + AMER1*:​CK1_gamma_*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome map
  19. IDAX*@Cytoplasm map + DVL*@Cytoplasm map map DVL*:​IDAX*@Cytoplasm map
  20. APC|​T1487_pho:​CTBP*|​hm2:​HDAC1_2*@Nucleus map + BCL9:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map map APC|​T1487_pho:​BCL9:​CTBP*|​hm2:​DVL*:​HDAC1_2*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map
  21. APC|​T1487_pho:​BCL9:​CTBP*|​hm2:​DVL*:​HDAC1_2*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map map APC|​T1487_pho:​_beta_-Catenin*|​K345_ace|​ace@Nucleus map + CTBP*:​p300*@Nucleus map + CTBP*:​HDAC1_2*:​LEF_TCF*:​WRE*@Nucleus map + DVL*:​JUN|​pho|​pho@Nucleus map
  22. HDAC1_2*:​LEF_TCF*:​TLE*|​ubi:​WRE*@Nucleus map + BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus map map BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_emp|​ace|​ace@Nucleus map + HDAC1_2*:​TLE*|​ubi@Nucleus map
  23. HIPK1@Nucleus map + DVL*@Nucleus map map DVL*:​HIPK1@Nucleus map
  24. DVL*@Nucleus map map DVL*@Cytoplasm map
  25. DVL*@Cytoplasm map map DVL*@Nucleus map
  26. JUN|​pho|​pho@Nucleus map + DVL*@Nucleus map map DVL*:​JUN|​pho|​pho@Nucleus map
  27. BCL9:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map + DVL*:​JUN|​pho|​pho@Nucleus map map BCL9:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map
  28. DVL*:​JUN|​pho|​pho@Nucleus map + BCL9:​CBP*|​S92_pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus map map BCL9:​CBP*|​S92_pho:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​ace|​ace@Nucleus map
  29. HDAC1_2*:​LEF_TCF*:​TLE*|​ubi:​WRE*@Nucleus map + BCL9:​DVL*:​JUN|​pho|​pho:​PYGO*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map map BCL9:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map + HDAC1_2*:​TLE*|​ubi@Nucleus map
  30. RAC1@Cytoplasm map + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​FZD*:​PAR6*:​PRR*:​RAC1:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  31. APC2*:​GSK3*@Cytoplasm map + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map map APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  32. G_alpha__sub_13q_endsub_*:​_beta_-Arrestin*@Cytoplasm map + DVL*|​pho|​emp|​emp@Cytoplasm map map DVL*|​pho:​G_alpha__sub_13q_endsub_*:​_beta_-Arrestin*@Cytoplasm map
  33. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho|​ubi:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map + RSPO3@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRR*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map + SMURF1@Cytoplasm map + PRICKLE1|​pho|​ubi@Cytoplasm map
  34. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRR*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  35. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRR*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  36. DVL*|​pho:​G_alpha__sub_13q_endsub_*:​_beta_-Arrestin*@Cytoplasm map map DVL*|​pho:​G_alpha__sub_13q_endsub_*:​_beta_-Arrestin*@Cytoplasm map
  37. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​FZD*:​PAR6*:​PRR*:​RAC1:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map map RAC1@Cytoplasm map + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  38. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WNT*:​_beta_-Arrestin2*@Endosome map + WGEF*@Cytoplasm map + DAAM1@Cytoplasm map + RHOA@Cytoplasm map map APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​pho|​pho:​GSK3*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​_beta_-Arrestin2*@Cytoplasm map
  39. APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​pho|​pho:​GSK3*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​_beta_-Arrestin2*@Cytoplasm map map Angiogenesis@Nucleus map
  40. APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​pho|​pho:​GSK3*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​_beta_-Arrestin2*@Cytoplasm map map APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​pho|​pho:​GSK3*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​_beta_-Arrestin2*@Cytoplasm map + RHOA@Cytoplasm map
  41. DVL*@Cytoplasm map map DVL*|​pho|​emp|​emp@Cytoplasm map
  42. DVL*|​pho:​G_alpha__sub_13q_endsub_*:​_beta_-Arrestin*@Cytoplasm map map _beta_-catenin stability@Nucleus map
  43. DVL*@Cytoplasm map map DVL*|​pho|​pho|​pho@Cytoplasm map
  44. CK1_epsilon_*:​CTHRC1:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*@Cytoplasm map + DVL*|​pho|​emp|​emp:​_beta_-Arrestin2*@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map
  45. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map map WNT canonical pathway@Cytoplasm map
  46. _beta_-Arrestin2*@Cytoplasm map + DVL*|​pho|​pho|​pho@Cytoplasm map map DVL*|​pho|​emp|​emp:​_beta_-Arrestin2*@Cytoplasm map
  47. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map map APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  48. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map map APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WNT*:​_beta_-Arrestin2*@Endosome map
  49. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​ROR2|​S864_emp|​emp|​emp:​SYN4*:​VANGL*|​emp|​emp|​emp|​emp:​_beta_-Arrestin2*@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​PRICKLE1|​pho:​ROR2|​S864_emp|​emp|​emp:​SYN4*:​VANGL*|​emp|​emp|​emp|​emp:​_beta_-Arrestin2*@Cytoplasm map + DVL*|​pho|​emp|​emp|​ubi@Cytoplasm map
  50. DVL*|​pho|​emp|​emp|​ubi@Cytoplasm map map degraded
  51. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​ROR2|​S864_emp|​emp|​emp:​SYN4*:​VANGL*|​emp|​emp|​emp|​emp:​_beta_-Arrestin2*@Cytoplasm map
  52. SMURF1@Cytoplasm map + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map
  53. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho|​ubi:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map
  54. DACT1@Cytoplasm map + DVL*@Cytoplasm map map DACT1:​DVL*@Cytoplasm map
  55. DACT1:​DVL*@Cytoplasm map map degraded
  56. s_s_wnc2_s5 + DVL*@Cytoplasm map map s_s_wnc2_s13
  57. APC@Cytoplasm map + HTID1_50_48_kDa_isoform*@Cytoplasm map + HSP70*@Cytoplasm map + DVL*@Cytoplasm map + Actin cytoskeletal*@Cytoplasm map + AXIN*@Cytoplasm map + HSC70*@Cytoplasm map map AXIN*:​DVL*:​HSC70*:​HTID1_50_48_kDa_isoform*@Cytoplasm map

As Catalyser:

  1. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map map AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map

  2. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map
  3. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome map map AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome map
  4. gGenes under control of _br_CBP-mediated transcription*@Nucleus map map rRNA@Nucleus map
  5. gTCF4@Nucleus map map rTCF4@Nucleus map
  6. gRAD6B*@Nucleus map map rRAD6B*@Nucleus map
  7. gBCL9@Nucleus map map rBCL9@Nucleus map
  8. gMIR372@Nucleus map map arMIR372@Nucleus map
  9. gMIR373@Nucleus map map arMIR373@Nucleus map
  10. gIRS2@Nucleus map map rIRS2@Nucleus map
  11. gCRIPTO-1*@Nucleus map map rCRIPTO-1*@Nucleus map
  12. gMYC@Nucleus map map rMYC@Nucleus map
  13. gGene under control of_br_ P300-mediated transcription*@Nucleus map map rRNA@Nucleus map
  14. ATP6V0C_D*@Cytoplasm map map ATP6V0C_D*@Endosome map
  15. ATP6V0C_D*@Cytoplasm map map ATP6V0C_D*@Endosome map
  16. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map map APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map

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