Protein DSTN

Identifiers
destrin (actin depolymerizing factor)
HUGO:DSTN HGNC:15750 ENTREZ:11034 UNIPROT:P60981 GENECARDS:DSTN KEGG:11034 ATLASONC:GC_DSTN WIKI:DSTN

Maps_Modules
 EMT   / EMT_REGULATORS 
 EMT   / CYTOSKELETON_POLARITY 

DSTN@Cytoplasm

References
e_re850( EMT  ):
CDC42 promotes changes in actin cytoskeleton by several pathways.
PMID:10461188
PMID:11950587
PMID:11340065
PMID:10559936
PMID:10613909
PMID:11413130
CDC42 activates PAK1,2,3,4 and CDC42BPA (MRCKalpha) which phosphorylate LIMK1,2.
LIMK1,2 subsquently phosphorylate and inhibit Cofilin
Destrin as actin depolymerizing factor, once phosphorylated by LIMK1,2 is inactive and thus this phosphorylation leads to actin polymerization and stimulation of filopodia and stress fibers formation.

DSTN|​pho@Cytoplasm

References
e_re850( EMT  ):
CDC42 promotes changes in actin cytoskeleton by several pathways.
PMID:10461188
PMID:11950587
PMID:11340065
PMID:10559936
PMID:10613909
PMID:11413130
CDC42 activates PAK1,2,3,4 and CDC42BPA (MRCKalpha) which phosphorylate LIMK1,2.
LIMK1,2 subsquently phosphorylate and inhibit Cofilin
Destrin as actin depolymerizing factor, once phosphorylated by LIMK1,2 is inactive and thus this phosphorylation leads to actin polymerization and stimulation of filopodia and stress fibers formation.

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Modifications:
In compartment: Cytoplasm

1. DSTN@Cytoplasm

2. DSTN|​pho@Cytoplasm

Participates in complexes:
In compartment: Cytoplasm

1. Actin cytoskeletal*:​DSTN@Cytoplasm

Participates in reactions:
As Reactant or Product:

1. DSTN@Cytoplasm → DSTN|​pho@Cytoplasm

2. DSTN@Cytoplasm + Actin cytoskeletal*@Cytoplasm → Actin cytoskeletal*:​DSTN@Cytoplasm
3. Actin cytoskeletal*:​DSTN@Cytoplasm → Actin polymerization@Nucleus

As Catalyser: