Identifiers
destrin (actin depolymerizing factor)
HUGO:DSTN HGNC:15750 ENTREZ:11034 UNIPROT:P60981 GENECARDS:DSTN KEGG:11034 ATLASONC:GC_DSTN WIKI:DSTN
Maps_Modules
EMT / EMT_REGULATORS
EMT / CYTOSKELETON_POLARITY
DSTN@Cytoplasm
References
e_re850( EMT ):
CDC42 promotes changes in actin cytoskeleton by several pathways.
PMID:10461188
PMID:11950587
PMID:11340065
PMID:10559936
PMID:10613909
PMID:11413130
CDC42 activates PAK1,2,3,4 and CDC42BPA (MRCKalpha) which phosphorylate LIMK1,2.
LIMK1,2 subsquently phosphorylate and inhibit Cofilin
Destrin as actin depolymerizing factor, once phosphorylated by LIMK1,2 is inactive and thus this phosphorylation leads to actin polymerization and stimulation of filopodia and stress fibers formation.
DSTN|pho@Cytoplasm
References
e_re850( EMT ):
CDC42 promotes changes in actin cytoskeleton by several pathways.
PMID:10461188
PMID:11950587
PMID:11340065
PMID:10559936
PMID:10613909
PMID:11413130
CDC42 activates PAK1,2,3,4 and CDC42BPA (MRCKalpha) which phosphorylate LIMK1,2.
LIMK1,2 subsquently phosphorylate and inhibit Cofilin
Destrin as actin depolymerizing factor, once phosphorylated by LIMK1,2 is inactive and thus this phosphorylation leads to actin polymerization and stimulation of filopodia and stress fibers formation.
Modifications:
In compartment: Cytoplasm
Participates in complexes:
In compartment: Cytoplasm
Participates in reactions:
As Reactant or Product:
- DSTN@Cytoplasm
→
DSTN|pho@Cytoplasm
- DSTN@Cytoplasm
+ Actin cytoskeletal*@Cytoplasm
→
Actin cytoskeletal*:DSTN@Cytoplasm
- Actin cytoskeletal*:DSTN@Cytoplasm
→
Actin polymerization@Nucleus
As Catalyser: