DP1*:E2F1

Complex DP1*:E2F1 map


Complex composition:

  1. DP1* map
  2. E2F1 map




DP1*:​E2F1@Nucleus

Identifiers
NAME:DP1*:E2F1

Maps_Modules
 Cell cycle  map  / E2F1  map
 Cell cycle  map  / RB  map

References
c_re291:( Cell cycle  map ) PMID:8380224; PMID:9315635; PMID:10773440
c_re292:( Cell cycle  map ) PMID:10753885
c_re64( Cell cycle  map ):
Acetylation of E2F1 (or activators E2Fs) on 3 lysine residues by PCAF increases its DNA-binding activity, stabilizes the protein and stimulates its transactivation potentiel.
PMID:15126619
Stabilisation of E2F1 by acetylation of Lys-117, Lys-120 and Lys-125 by PCAF and, to a lesser extent, p300 acetyltransferases.
PMID:15123636
Acetylated lysines on E2F1 are conserved and acetylated on E2F2 and E2F3. Acetylation by p300/CBP.
PMID:10753885

Confidence
REF=4 FUNC=5

DP1*:​E2F1|​Lys_ace@Nucleus

Identifiers
NAME:DP1*:E2F1

Maps_Modules
 Cell cycle  map  / E2F1  map

References
c_re64( Cell cycle  map ):
Acetylation of E2F1 (or activators E2Fs) on 3 lysine residues by PCAF increases its DNA-binding activity, stabilizes the protein and stimulates its transactivation potentiel.
PMID:15126619
Stabilisation of E2F1 by acetylation of Lys-117, Lys-120 and Lys-125 by PCAF and, to a lesser extent, p300 acetyltransferases.
PMID:15123636
Acetylated lysines on E2F1 are conserved and acetylated on E2F2 and E2F3. Acetylation by p300/CBP.
PMID:10753885

Confidence
REF=2 FUNC=5

DP1*:​E2F1|​Lys_ace|​Ser364_pho@Nucleus

Identifiers
NAME:DP1*:E2F1

Maps_Modules
 Cell cycle  map  / E2F1  map

References
c_re621( Cell cycle  map ):
Protein stabilized by phosphorylation.
PMID:15838517, PMID:15140942

Confidence
REF=1 FUNC=5

DP1*:​E2F1|​Lys_ace|​Ser31_pho@Nucleus

Identifiers
NAME:DP1*:E2F1

Maps_Modules
 Cell cycle  map  / E2F1  map

References
c_re622( Cell cycle  map ):
Upon DNA damage, E2F is stabilized by ATM phosphorylation.
PMID:15838517, PMID:15140942
14-3-3 tau mediates E2F1 stabilization. 14-3-3 tau interacts with ATM-phosphorylated E2F1 during DNA damage and inhibits E2F1 ubiquitination. 14-3-3 tau is also required for expression and induction of E2F1 apoptotic targets, such as p73, Apaf-1, and caspases, during DNA damage.
PMID:15494392
c_re139( Cell cycle  map ):
Upon DNA damage and ATM phosphorylation, the transcriptional activity, the apoptotic and the S phase-inducing activites of E2F1 are inhibited by binding to TopBP1 (inhibition RB-independant). Induce damage repair.
PMID:15838517, PMID:12697828

Confidence
REF=3 FUNC=5


Modifications:
Participates in complexes:
In compartment: Nucleus
  1. DP1*:​E2F1@Nucleus map

  2. DP1*:​E2F1|​Lys_ace@Nucleus map
  3. DP1*:​E2F1|​Lys_ace|​Ser31_pho@Nucleus map
  4. DP1*:​E2F1|​Lys_ace|​Ser364_pho@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. DP1*:​E2F1|​Lys_ace|​Ser31_pho@Nucleus map + TOPBP1@Nucleus map map DP1*:​E2F1|​Lys_ace|​Ser31_pho:​TOPBP1@Nucleus map

  2. DP1*:​E2F1:​RB1|​pho|​pho|​pho@Nucleus map map RB1|​pho|​pho|​pho@Nucleus map + DP1*:​E2F1@Nucleus map
  3. DP1*:​E2F1|​Lys_ace@Nucleus map map DP1*:​E2F1@Nucleus map
  4. DP1*:​E2F1|​Lys_ace@Nucleus map + PCAF*@Nucleus map map DP1*:​E2F1|​Lys_ace:​PCAF*@Nucleus map
  5. E2F1@Nucleus map + DP1*@Nucleus map map DP1*:​E2F1@Nucleus map
  6. DP1*:​E2F1|​Lys_ace:​PCAF*@Nucleus map map PCAF*@Nucleus map + DP1*:​E2F1|​Lys_ace|​Ser364_pho@Nucleus map
  7. DP1*:​E2F1|​Lys_ace:​PCAF*@Nucleus map map DP1*:​E2F1|​Lys_ace|​Ser31_pho@Nucleus map + PCAF*@Nucleus map
  8. DP1*:​E2F1@Nucleus map map DP1*:​E2F1|​Lys_ace@Nucleus map
  9. DP1*:​E2F1@Nucleus map + RB1@Nucleus map map DP1*:​E2F1:​RB1@Nucleus map

As Catalyser:

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