DNA replicarion

Phenotype DNA replicarion map
DNA replicarion@default

 DNA repair  map  / S_CC_PHASE  map

d_re437( DNA repair  map ):
For role of TIM1*/TIPIN in S-phase checkpoint, stalled replication forks stabilisation and DNA repair during S-phase:
PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221
Stalled replication forks induce PCNA mono-ubiquitylation and formation of the complex that activated TLS and arrests S-phase:
PMID:19793801, PMID:17582221, PMID:19158510, PMID:18451105
d_re119( DNA repair  map ):
For inhibition of S-checkpoint by ATM:
PMID:15175241, PMID:12086603
For inhibition of S-checkpoint by HCLK2/FAAP24/ATR/FANKM complex:
PMID:19282663, PMID:19622404, PMID:18995830
For interaction between SNM1B and ATM to mediate S-phase checkpoint in response to ICL (intra-chromatide lesion):
Resected DNA is a triger for activating the S-phase checkpoint and moving from G1 to S to G2:
PMID:20051983, PMID:16805667
For inhibition of S to G2 propagation and activation of S-phase checkpoint by complex PCNA:CtIP:
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair. ATR/ATRIP S phase arrest is activated:
For inhibition of S-phase by ATR/ATRIP/CHEK1/CLSPN/HCLK2* complex:
PMID:19793801, PMID:17384638
For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint
Formation of the complex for crosslink-activation of S phase checkpoint. FA core complex activates the reaction to stop S-phase propagaton:
PMID:14988723, PMID:15136767

In compartment: default
  1. DNA replicarion@default map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. No DNA replicarion@default map map DNA replicarion@default map

    As Catalyser:

    1. S phase@default map map G2 phase@default map

    2. CDK1@default map + CyclinB1*@default map map CDK1:​CyclinB1*@default map
    3. CyclinA1*@default map + CDK1@default map map CDK1:​CyclinA1*@default map
    4. Securin*:​Separin*@default map map Securin*@default map + Separin*@default map
    5. SCC1*:​SMC1*:​SMC3:​STAG*@default map map STAG*@default map + SCC1*@default map + SMC3@default map + SMC1*@default map

    Leave a Reply