DNA-PK*:Ku70*:Ku80*:WRN

Complex DNA-PK*:Ku70*:Ku80*:WRN map


Complex composition:

  1. Ku80* map
  2. Ku70* map
  3. WRN map
  4. DNA-PK* map




DNA-PK*:​Ku70*:​Ku80*:​WRN@Nucleus

Identifiers
NAME:DNA-PK*:Ku70*:Ku80*:WRN

References
PMID:23082994
WRN inhibits C_NHEJ by sequestering DNA-PKs
PMID:12202749
d_re566( DNA repair  map ):
Binding between Ku70/80/DNA-PK and WRN inhibits Ku activity
PMID:17303082
WRN is a key activator of alt_NHEJ pathway
PMID:18524993
C_NHEJ and A_NHEJ are competing mechanisms
PMID:24050180

Confidence
REF=4 FUNC=5


Modifications:
Participates in complexes:
In compartment: Nucleus
  1. DNA-PK*:​Ku70*:​Ku80*:​WRN@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. Ku80*@default map + Ku70*@default map + WRN@Nucleus map + DNA-PK*@default map map DNA-PK*:​Ku70*:​Ku80*:​WRN@Nucleus map

As Catalyser:

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