DNA-PK*

Protein DNA-PK* map

Identifiers
protein kinase, DNA-activated, catalytic polypeptide
HUGO:PRKDC HGNC:9413 ENTREZ:5591 UNIPROT:P78527 GENECARDS:PRKDC REACTOME:62162 KEGG:5591 ATLASONC:GC_PRKDC WIKI:PRKDC

Maps_Modules
 Apoptosis  map  / AKT_MTOR  map
 DNA repair  map  / C_NHEJ  map

References
synonym:DNAPK
PMID:19772495, PMID:19346677, PMID:15703371, PMID:19847258, PMID:16697054, PMID:19473888, PMID:19808869, PMID:19772495, PMID:21376743
PMID:21300785, PMID:21175350, PMID:20691907

DNA-PK*@Nucleus

References
a_re1248:( Apoptosis  map ) PMID:7500007

DNA-PK*|​unk@Nucleus

References
a_re1046( Apoptosis  map ):
PMID:12234250
in G361 human melanoma cells, upon ionizing radiations
in vitro by ATM and DNAPK
in Hela, ectopically expressed LKB1 T366-phosphorylated is located in the nucleus
PMID:20160076
in HeLa S3 cells that lack functional LKB1, reexpression of wild-type but not T366A LKB1 restored the ability to repress mTORC1 in response to H2O2
in MCF7, LKB1 is located in the cytoplasm, together with a proportion of ATM. H2O2 induces phosphorylation of cytoplasmic LKB1, but not other DNA damaging agents (etoposide). This supports a possible H2O2-induced and DNA damage-independent activation of the cytoplasmic of ATM responsible for LKB1 phosphorylation.
a_re1401:( Apoptosis  map ) PMID:19203584

DNA-PK*|​pho@default

References
d_re82:( DNA repair  map ) PMID:21376743

DNA-PK*|​hm2|​active@default

References
d_re85:( DNA repair  map ) PMID:9242410
d_re95:( DNA repair  map ) PMID:11955432, PMID:19772495
d_re132:( DNA repair  map ) PMID:19841479, PMID:19793861
d_re383:( DNA repair  map ) PMID:9892021

DNA-PK*@default

References
d_re43:( DNA repair  map ) PMID:16731533
d_re82:( DNA repair  map ) PMID:21376743
d_re90( DNA repair  map ):
PMID:9488723, PMID:19772495
PMID:17303408
d_re94:( DNA repair  map ) PMID:16093244
d_re566( DNA repair  map ):
Binding between Ku70/80/DNA-PK and WRN inhibits Ku activity
PMID:17303082
PMID:12202749
WRN is a key activator of alt_NHEJ pathway
PMID:18524993
C_NHEJ and A_NHEJ are competing mechanisms
PMID:24050180


Modifications:
In compartment: Nucleus
  1. DNA-PK*@Nucleus map

  2. DNA-PK*|​unk@Nucleus map

In compartment: default

  1. DNA-PK*@default map

  2. DNA-PK*|​pho@default map
  3. DNA-PK*|​hm2|​active@default map

Participates in complexes:
In compartment: Nucleus

  1. DNA-PK*:​Ku70*:​Ku80*:​WRN@Nucleus map

  2. Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​PARP3@Nucleus map
  3. APLF:​Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​LIG4:​PARP3:​XLF*:​XRCC4|​hm2@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. DNA-PK*@Nucleus map map DNA-PK*|​unk@Nucleus map

  2. DNA-PK*@Nucleus map map cleaved~DNA-PK*@Nucleus map
  3. Ku80*@default map + Ku70*@default map + WRN@Nucleus map + DNA-PK*@default map map DNA-PK*:​Ku70*:​Ku80*:​WRN@Nucleus map
  4. DNA-PK*@default map map DNA-PK*|​pho@default map
  5. DNA-PK*@default map map DNA-PK*|​hm2|​active@default map
  6. Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho|​active@default map + LIG4:​XLF*:​XRCC4|​hm2@default map + PARP3@Nucleus map + DNA-PK*|​hm2|​active@default map + Ku80*@default map + Ku70*@Nucleus map + APLF@Nucleus map map APLF:​Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​LIG4:​PARP3:​XLF*:​XRCC4|​hm2@Nucleus map
  7. DNA-PK*|​hm2|​active@default map + Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho|​active@default map + Ku70*:​Ku80*@Nucleus map + PARP3@Nucleus map map Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​PARP3@Nucleus map

As Catalyser:

  1. STK11|​K48_unk@Nucleus map map STK11|​K48_unk|​T366_pho@Nucleus map

  2. Caspase2*@Nucleus map map Caspase2*|​S122_pho@Nucleus map
  3. gA_NHEJ_DNA_st1*@Nucleus map map gA_NHEJ_DNA_st2*@Nucleus map
  4. SMARCAL1@default map map SMARCAL1|​pho@default map
  5. Securin*@default map map Securin*|​S165_pho@default map
  6. RPA2@default map map RPA2|​pho@default map
  7. gC_NHEJ_DNA_st3*@Nucleus map map gC_NHEJ_DNA_st4*@Nucleus map
  8. DNA-PK*@default map map DNA-PK*|​pho@default map
  9. H2AFX@default map map H2AFX|​pho@default map
  10. Artemis*@default map map Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho|​active@default map
  11. gC_NHEJ_DNA_st4*@Nucleus map map gC_NHEJ_DNA_st5*@Nucleus map

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