DIAPH1

Protein DIAPH1 map

Identifiers
diaphanous homolog 1 (Drosophila)
HUGO:DIAPH1 HGNC:2876 ENTREZ:1729 UNIPROT:O60610 GENECARDS:DIAPH1 KEGG:1729 ATLASONC:GC_DIAPH1 WIKI:DIAPH1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

References
PMID:15866170
DRFs (DIAPH1,2,3) are autoinhibited through intramolecular binding of a Diaphanous autoinhibitory domain to a conserved N-terminal regulatory element.
Autoinhibition is relieved through binding of the GTPase RhoA to the N-terminal element.
PMID:16292343
DRFs are regulated by a RhoGTPase-binding domain situated in the N-terminal region and a C-terminal Diaphanous-autoregulatory domain, whose interaction stabilises an autoinhibited inactive conformation.
Binding of active Rho releases DAD and activates the catalytic activity of mDia
PMID:17575049
Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion.

DIAPH1@Cytoplasm

References
e_re702( EMT  map ):
PMID:17575049
Positive feedback between Dia1 (so-called DIAPH1), LARG (so-called ARHGEF12), and RhoA regulates cell morphology and invasion.
The FH2 domain of Dia1 stimulates the guanine nucleotide exchange activity of LARG in vitro.
Dia1 is necessary for LPA-stimulated Rho-ROCK signaling and bleb-associated cancer cell invasion.
Thus, Dia1-dependent RhoA activation constitutes a positive feedback mechanism to modulate cell behavior.
Dia1 is required and sufficient for full LPA- induced activation of RhoA and downstream ROCK signaling. This effect can be mediated through interaction of Dia1 with LARG
Dia1, in addition to its role as a downstream RhoA effector, can function upstream of RhoA.


Modifications:
In compartment: Cytoplasm
  1. DIAPH1@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. DIA*|​closed@Cytoplasm map map DIAPH1@Cytoplasm map

    2. DIAPH1@Cytoplasm map map ARHGEF12@Cytoplasm map
    3. RhoB_cytoskeletal_effectors*@Cytoplasm map map DIAPH1@Cytoplasm map
    4. RhoA_cytoskeletal_effectors*@Cytoplasm map map DIAPH1@Cytoplasm map

    As Catalyser:

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