DIA*:GTP:RHOA

Complex DIA*:GTP:RHOA map


Complex composition:

  1. RHOA map
  2. GTP map
  3. DIA* map




DIA*|​open:​GTP:​RHOA@Cytoplasm

Identifiers
NAME:DIA*:GTP:RHOA

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

References
PMID:15866170
DRFs (DIAPH1,2,3) are autoinhibited through intramolecular binding of a Diaphanous autoinhibitory domain to a conserved N-terminal regulatory element.
Autoinhibition is relieved through binding of the GTPase RhoA to the N-terminal element.
PMID:16292343
DRFs are regulated by a RhoGTPase-binding domain situated in the N-terminal region and a C-terminal Diaphanous-autoregulatory domain, whose interaction stabilises an autoinhibited inactive conformation.
Binding of active Rho releases DAD and activates the catalytic activity of mDia
PMID:17575049
Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion.

Confidence
REF=3 FUNC=3


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. DIA*|​open:​GTP:​RHOA@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. GTP:​RHOA@Cytoplasm map + DIA*|​closed@Cytoplasm map map DIA*|​open:​GTP:​RHOA@Cytoplasm map

As Catalyser:

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