DRFs (DIAPH1,2,3) are autoinhibited through intramolecular binding of a Diaphanous autoinhibitory domain to a conserved N-terminal regulatory element.
Autoinhibition is relieved through binding of the GTPase RhoA to the N-terminal element.
DRFs are regulated by a RhoGTPase-binding domain situated in the N-terminal region and a C-terminal Diaphanous-autoregulatory domain, whose interaction stabilises an autoinhibited inactive conformation.
Binding of active Rho releases DAD and activates the catalytic activity of mDia
Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion.
Participates in complexes:
In compartment: Cytoplasm
Participates in reactions:
As Reactant or Product: