DIABLO

Protein DIABLO map

Identifiers
diablo, IAP-binding mitochondrial protein
HUGO:DIABLO HGNC:21528 ENTREZ:56616 UNIPROT:Q9NR28 GENECARDS:DIABLO REACTOME:64638 KEGG:56616 ATLASONC:DIABLOID42995ch12q24 WIKI:DIABLO

Maps_Modules
 Apoptosis  map  / CASPASES  map
 Apoptosis  map  / TNF_RESPONSE  map

DIABLO@Cytoplasm

References
a_re2( Apoptosis  map ):
hierarchical:post-MOMP
PMID:14532003
PMID:10929711
PMID:12660240
in Hela upn taxol treatment
a_re657:( Apoptosis  map ) PMID:15300255
a_re736( Apoptosis  map ):
identification of DIABLO as an inhibitor of XIAP
PMID:11140637
structure of XIAP BIR3 complexed to a peptide from DIABLO
PMID:15078891
DIABLO inhibits XIAP ubiquitin-ligase activity
a_re737( Apoptosis  map ):
in Hela, upon taxol treatment, interaction detected by GST pull-down, BIRC5 antagonizes DIABLO pro-apoptotic effect
a_re738( Apoptosis  map ):
PMID:11801603
in 293T, interaction between ectopically expressed proteins
in vitro, interaction between a DIABLO peptide and the BIR domain of ML-IAP
in 293T, binding of DIABLO to BIRC7 antagonizes the binding of processed CASP9
a_re1160( Apoptosis  map ):
PMID:18022362
SMAC mimetic induces cIAP auto-ubiquitinylation and degradation
PMID:18022363

DIABLO@Mitochondrial intermembrane space

References
a_re2( Apoptosis  map ):
hierarchical:post-MOMP
PMID:14532003
PMID:10929711
PMID:12660240
in Hela upn taxol treatment

DIABLO|​ubi@Cytoplasm

References
a_re657:( Apoptosis  map ) PMID:15300255


Modifications:
In compartment: Cytoplasm
  1. DIABLO@Cytoplasm map

  2. DIABLO|​ubi@Cytoplasm map

In compartment: Mitochondrial intermembrane space

  1. DIABLO@Mitochondrial intermembrane space map

Participates in complexes:
In compartment: Cytoplasm

  1. BIRC7:​DIABLO@Cytoplasm map

  2. DIABLO:​XIAP|​S87_unk@Cytoplasm map
  3. BIRC5|​T34_pho:​DIABLO@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. DIABLO@Mitochondrial intermembrane space map map DIABLO@Cytoplasm map

  2. DIABLO@Cytoplasm map map DIABLO|​ubi@Cytoplasm map
  3. DIABLO|​ubi@Cytoplasm map map degraded
  4. XIAP|​S87_unk@Cytoplasm map + DIABLO@Cytoplasm map map DIABLO:​XIAP|​S87_unk@Cytoplasm map
  5. BIRC5|​T34_pho@Cytoplasm map + DIABLO@Cytoplasm map map BIRC5|​T34_pho:​DIABLO@Cytoplasm map
  6. DIABLO@Cytoplasm map + BIRC7@Cytoplasm map map BIRC7:​DIABLO@Cytoplasm map

As Catalyser:

  1. cIAP*@TNFRSF1 Receptor Complex map map cIAP*|​ubi@TNFRSF1 Receptor Complex map

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