Damaged_DNA*

Gene Damaged_DNA* map

Identifiers
Damaged DNA
Node_Type:Generic

References
PMID:23892398

gDamaged_DNA*@Nucleus

References
d_re175:( DNA repair  map ) reactionType:is.a
d_re180( DNA repair  map ):
Phosphorylated Rev1 is the activator and the modulator of the TLC pathway in response to DNA damage and by cell cycle regulation
PMID:17035102
Several TLS polymerases participate in Fanconi in combination with HR and NER
PoL iota bypasses T-T adducts and dA-N6_BPDE, but only with assistance of Polkappa or Pol zeta:
PMID:15189446, PMID:12466554 (major)
Depending on the DNA damage, different TLS polymerases will be activated:
PMID:19225445
REV1 interacts with many TLS polymerases:
PMID:14657033
Polyubiquitination of PCNA activates prone-free mechanisms of lesions by-pass
PMID:19217833, PMID:18157158,
For TLS PMID:19258535
d_re185( DNA repair  map ):
For hyper-phosphotyration of REV1 in cell cycle and DNA damage-dependent manner. Hyper-phosphorylation makes REV1 regulatory molecule for activating TLS pathway
PMID:17035102, PMID:19258535


Modifications:
In compartment: Nucleus
  1. gDamaged_DNA*@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. gTC-NER_DNA_st2*@Nucleus map map gDamaged_DNA*@Nucleus map

    2. gGG-NER_DNA_st1*@Nucleus map map gDamaged_DNA*@Nucleus map
    3. gOxidized_ring-saturated_hydrolysed_base*@Nucleus map map gDamaged_DNA*@Nucleus map
    4. gDeaminated_alkylated_mismatched_base*@Nucleus map map gDamaged_DNA*@Nucleus map
    5. gMismatched_nucleotide*@Nucleus map map gDamaged_DNA*@Nucleus map
    6. gDamaged_DNA*@Nucleus map map gRepaired_DNA*@Nucleus map
    7. gHR_DNA_st1*@Nucleus map map gDamaged_DNA*@Nucleus map
    8. gC_NHEJ_DNA_st1*@Nucleus map map gDamaged_DNA*@Nucleus map
    9. gA_NHEJ_DNA_st1*@Nucleus map map gDamaged_DNA*@Nucleus map
    10. gSSA_DNA_st1*@Nucleus map map gDamaged_DNA*@Nucleus map
    11. gTLS_DNA_st1*@Nucleus map map gDamaged_DNA*@Nucleus map
    12. gDR_DNA_st1*@Nucleus map map gDamaged_DNA*@Nucleus map

    As Catalyser:

    1. RAD18@default map + RAD6*@default map map RAD18:​RAD6*@default map

    2. REV1|​pho@default map map REV1|​pho|​pho|​pho@default map
    3. gUSP1@default map map rUSP1@default map

    Leave a Reply