d_re80

Reaction state_transition d_re80 map

gC_NHEJ_DNA_st1*@Nucleus map gC_NHEJ_DNA_st2*@Nucleus map

Reaction regulators:

Catalysis
  1. Ku70*:​Ku80*:​Securin*@default map
  2. Ku70*:​Ku80*@Nucleus map
  3. G1 phase@default map
Inhibition
  1. BRCA1:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi:​MRE11*:​NBS1*|​S343_pho:​PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho:​RAD50@default map



References
The complex MRN:BRCA1:phos-Ub-CtIP is central in the shift toward HR, because it activates resection for HR and blocks Ku70/80 of C_NHEJ:
PMID:19357644, PMID:15485915, PMID:19490890, PMID:18716619 (for CDK-dep phosph), PMID:20051983

Confidence
REF=3 FUNC=4


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