d_re517

Reaction state_transition d_re517 map

gIntact_DNA*@Nucleus map gGG-NER_DNA_st1*@Nucleus map

Reaction regulators:

Catalysis
  1. UV@Nucleus map
  2. Interstrand crosslinking agents*@Nucleus map
  3. Alkylating agents*@Nucleus map
  4. Lipid peroxides*@Nucleus map
  5. ROS@Nucleus map



References
UV light causes bulky adducts damage in DNA that repared by NER pathway
For activation of NER by UV
PMID:22743272, PMID:22822215, PMID:22492724, PMID:22373527
Interstrand crosslinking agents induce NER
PMID:21701511
ROS activate NER for repating intrastrand crosslink
PMID:22581771
ROS activate NER for bulky adducts
PMID:18189366

Confidence
REF=4 FUNC=5


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