d_re489

Reaction state_transition d_re489 map

gTLS_DNA_st1*@Nucleus map gTLS_DNA_st2*@Nucleus map

Reaction regulators:

Boolean_logic_gate_and
  1. PCNA|​K164_ubi:​REV1@default map and BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@default map
Catalysis
  1. PCNA|​K164_ubi:​REV1@default map
  2. PCNA|​K164_ubi:​POLK:​REV1@default map
  3. PCNA|​K164_ubi:​POLH:​REV1@default map
  4. POLH:​RAD18:​RAD6*:​REV1@default map
  5. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@default map
  6. PCNA|​K164_ubi:​POLZ*@default map
  7. S phase@default map
Modulation
  1. POLZ*@default map
  2. REV1|​pho|​pho|​pho@default map



References
Reaction (id=re180, name=; CellCycle_DNArepair_18_12_2010_Version3.xml)
Phosphorilated Rev1 is the activator and the modulator of the TLC pathway in response to DNA damage and by cell cycle regulation
PMID:17035102
Several TLS polymerases participate in Fanconi in combination with HR and NER
PoL iota bypasses T-T adducts and dA-N6_BPDE, but only with assistance of Polkappa or Pol zeta:
PMID:15189446, PMID:12466554 (major)
Depending on the DNA damage, different TLS polymerases will be activated:
PMID:19225445
REV1 interacts with many TLS polymerases:
PMID:14657033
Polyubiquitination of PCNA activates prone-free mechanisms of lesions by-pass
PMID:19217833, PMID:18157158
For TLS
PMID:19258535
FA core complex regulates REV1 and activated TLS
PMID:22266823

Confidence
REF=5 FUNC=3


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