d_re36

Reaction state_transition d_re36 map

ATM@default map ATM|​pho|​S367_pho|​S1893_pho|​active@default map

Reaction regulators:

Boolean_logic_gate_and
  1. MLH1:​PMS2@default map and MSH2|​pho:​MSH6|​pho@default map
Catalysis
  1. CDK5@default map
  2. ATM@default map
Modulation
  1. MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  2. PPP5C@default map
  3. ATM|​pho|​S367_pho|​S1893_pho:​H2AFX|​pho|​ubi:​MDC1|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
Physical_stimulation
  1. MSH2|​pho:​MSH6|​pho@default map
  2. MLH1:​PMS2@default map
Trigger
  1. gC_NHEJ_DNA_st1*@Nucleus map
  2. gHR_DNA_st1*@Nucleus map
  3. gFanconi_DNA_st1*@Nucleus map
  4. gA_NHEJ_DNA_st1*@Nucleus map



References
PMID:16332722
Auto-phosphorylation of ATM in response to DNA DSB:
PMID:17303408, PMID:12556884, PMID:16858402
Amplification of ATM auto-phosphorylation by the complex ATM:MRNcomplex:H2AX:MDC1CDK5 phosphorylates and activates ATM
PMID:19151707

Confidence
REF=3 FUNC=4


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