d_re249

Reaction state_transition d_re249 map

BRCA1:​BRCA2:​FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default map BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default map

Reaction regulators:

Catalysis
  1. UAF1*:​USP1|​pho@default map



References
Fanconi pathway is regulated at two levels:1. FANCD2 and FANCI uiquitination by UBE2T for Fanconi foci association. Followed by FANCD2 and FANCI DE-uiquitination by USP1/UAF1 to allow the repair process:
PMID:19217432, PMID:18082604, PMID:19075014, PMID:18082605, PMID:19264559

Confidence
REF=4 FUNC=4


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