Reaction state_transition d_re165

gFanconi_DNA_st4*@Nucleus → gHR_DNA_st2*@Nucleus

Reaction regulators:

Catalysis

1. RPA1:​RPA2:​RPA3:​SMARCAL1|​pho@default
2. BRCA2:​FANCC:​FANCG|​S7_pho:​XRCC3@default
3. MRE11*:​NBS1*|​S343_pho:​RAD50@default
4. BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default

Modulation

1. BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​FANCJ*:​FANCN*:​RPA1:​RPA2:​RPA3@default
2. FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho:​POLN@default

References
Link between Fanconi pathway and HR.
Fanconi pathway is a coordination of NER, TLS and HR
PMID:19686080:G
POLH activates D-loop extension. PoLN:HEL308* participate in HR and Fanconi. PolN:FANCD2:FANCI complex activate HR:
PMID:16337602
For role of SMARCAL1/RPA in stalled replication fork repair and in the homologous recombination:
PMID:19841479, PMID:19793861, PMID:19793862

Confidence
REF=4 FUNC=4