d_re136

Reaction state_transition d_re136 map

gHR_DNA_st2*@Nucleus map gHR_DNA_st3*@Nucleus map

Reaction regulators:

Catalysis
  1. RPA1:​RPA2:​RPA3:​SMARCAL1|​pho@default map
  2. BRCA1:​FANCJ*|​S990_pho@default map
  3. DNA2@default map
  4. BARD1:​BRCA1:​BRCA2:​BRIT1*:​DSS1*:​FANCD2|​K561_ubi|​pho:​FANCN*:​RAD51:​RAD52:​SFPQ:​XRCC2:​XRCC3@default map
  5. RPA1:​RPA2:​RPA3@default map
Modulation
  1. UBE2N@default map
  2. MCM8*:​MCM9*@default map
  3. BRCA1:​BRCA2:​FANCD2|​pho:​FANCI|​pho:​H2AFX|​pho|​ubi:​NBS1*|​S343_pho:​PCNA:​RAD51:​TIP60*@default map
  4. H2AFX|​pho|​ubi:​MDC1|​pho@default map



References
Regulation of HR DNA repair foci formation regulation by UBc13:
PMID:17349954
For role of SMARCAL1/RPA in stalled relication fork repair and in the homologous recombination:
PMID:19841479, PMID:19793861, PMID:19793862
MCM8*/MCM9* colocolize at RAD51 filament and reqired for interstrand crosslinks repair
PMID:22771115

Confidence
REF=5 FUNC=4


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