d_re120

Reaction known_transition_omitted d_re120 map

G2 phase@default map M phase@default map

Reaction regulators:

Catalysis
  1. CDK1|​T161_pho:​CyclinB1*@default map
Inhibition
  1. FAAP24*:​FANCM@default map
  2. BRCA1:​FANCJ*|​S990_pho@default map
  3. CDK1:​CyclinB1*:​GADD45A@default map
  4. ATRIP:​ATR|​pho@default map
  5. CIP1_KIP1*@default map
  6. SCC1*|​ATM-dep._pho:​SMC1*|​S957_pho:​SMC3|​S1083_pho:​STAG*@default map
  7. p73*|​Y99_pho|​ace|​active@default map
  8. ATM|​pho|​S367_pho|​S1893_pho:​H2AFX|​pho|​ubi:​MDC1|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  9. MBD4:​MLH1@default map
  10. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@default map
Modulation
  1. BRCA2@default map
  2. FANCD2|​K561_ubi|​pho:​FANCI|​K523_ubi|​pho@default map
Trigger
  1. gRepaired_DNA*@Nucleus map
Unknown_inhibition
  1. HSP90*@default map



References
By CycB*/CDC2*:
G2/M transition
PMID:16818604
For BRCA2 and FANCD2/FANCDI importance in the cytokinesis and localisation at the spindle and role in the propagation of mitosis:
PMID:15375219, PMID:19686080
CDC2 has to be phosphorylated fot inhibition of G2 to M propagation (called G2 checkpoint). FANCC activates CDC2 phosphorylation
PMID:15377654
Brca1 ubiquitinates CtIp and in complex they inhibit G2 to M propagation (G2 checkpoint)
PMID:16818604, PMID:15485915
BRCA1 and FANCJ in complex inhibit G2 to M propagation (called G2 checkpoint).
PMID:15242590
FANCM:FAAP24 complex activated G2 phase checpoint (G2 to M propagation inhibition):
PMID:18995830
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair:
PMID:16713580, PMID:18543256
BER and MMR interaction and G2/M arrest inresponce to o6-meG formation:
PMID:14614141

Confidence
REF=5 FUNC=3


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