d_re119

Reaction known_transition_omitted d_re119 map

S phase@default map G2 phase@default map

Reaction regulators:

Catalysis
  1. CTIP*|​emp:​PCNA@default map
  2. DNA replicarion@default map
  3. (CDK2|​T160_pho:​CyclinA1*)|​active@default map
  4. (CDK1|​Y14/15_pho|​T161_pho:​CyclinA1*)|​active@default map
Inhibition
  1. FANCD2|​S222_pho@default map
  2. ATR|​pho:​FAAP24*:​FANCM:​HCLK2*@default map
  3. ATR|​pho:​FANCD2|​K561_ubi|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  4. ATM|​pho|​S367_pho|​S1893_pho:​SNM1B*@default map
  5. gHR_DNA_st2*@Nucleus map
  6. HUS1:​RAD1:​RAD17:​RAD9*:​RFC*@default map
  7. PPP5C@default map
  8. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​HCLK2*@default map
  9. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​PCNA|​K164_ubi:​TIM1*@default map
  10. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​RPA1:​RPA2:​RPA3:​TIM1*:​TIPIN@default map
  11. ATM|​pho|​S367_pho|​S1893_pho|​active@default map
  12. ATM|​pho|​S367_pho|​S1893_pho:​H2AFX|​pho|​ubi:​MDC1|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
Trigger
  1. gRepaired_DNA*@Nucleus map



References
For inhibition of S-checkpoint by ATM:
PMID:15175241, PMID:12086603
For inhibition of S-checkpoint by HCLK2/FAAP24/ATR/FANKM complex:
PMID:19282663, PMID:19622404, PMID:18995830
For interaction between SNM1B and ATM to mediate S-phase checkpoint in response to ICL (intra-chromatide lesion):
PMID:18469862
Resected DNA is a triger for activating the S-phase checkpoint and moving from G1 to S to G2:
PMID:20051983, PMID:16805667
For inhibition of S to G2 propagation and activation of S-phase checkpoint by complex PCNA:CtIP:
PMID:19342888
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair. ATR/ATRIP S phase arrest is activated:
PMID:16713580
For role of TIM1*/TIPIN in S-phase checkpoint, stalled replication forks stabilisation and DNA repair during S-phase:
PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221
For inhibition of S-phase by ATR/ATRIP/CHEK1/CLSPN/HCLK2* complex:
PMID:19793801, PMID:17384638
For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint
PMID:15798197
Formation of the complex for crosslink-activation of S phase checkpoint. FA core complex activates the reaction to stop S-phase propagaton:
PMID:14988723, PMID:15136767

Confidence
REF=5 FUNC=4


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