d_re114

Reaction state_transition d_re114 map

gHR_DNA_st1*@Nucleus map gHR_DNA_st2*@Nucleus map

Reaction regulators:

Catalysis
  1. SMC5:​SMC6@default map
  2. BLM:​EXO1@Nucleus map
  3. BRCA2:​FANCC:​FANCG|​S7_pho:​XRCC3@default map
  4. SMC1*|​S957_pho:​SMC3|​S1083_pho@default map
  5. BRCA1:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi:​MRE11*:​NBS1*|​S343_pho:​PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho:​RAD50@default map
  6. ATM|​pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map
  7. S phase@default map
  8. G2 phase@default map
Inhibition
  1. RECQL5 @default map
  2. PCNA|​K164_don|​K127_don@default map
  3. TP53BP1@default map
Modulation
  1. POLI@default map
  2. MDC1|​pho:​RNF8@default map
  3. H2AFX|​pho|​ubi:​MDC1|​pho@default map
Unknown_catalysis
  1. BLM:​RMI1:​TOP3A@default map



References
PMID:18171670, PMID:20064462
For regulation of HR by cell cycle. CDK1 is essential to switch cells from C_NHEJ to HR during S/G2 phase: PMID:15496928
The complex BRCA2:FANCC:FANCG:XRCC3 activates HR:
PMID:18212739
For role of BLM:TOP3:RMI1 complex in the HR resection step:
PMID:19490890
For central role of the MRN complex and CtIP in the resection of the DNA that turns on the HR and off C_NHEJ:
PMID:20021983
For inhibition of HR by RECQ5:
PMID:19270065
For role of CDC2 (CDK1) in DNA resection initiation in S/G2 phase, HR initiation:
PMID:15655342, PMID:15549137, PMID:15496928
RNF8:MDC1 complex recruit HR-related proteins by this shifting from C_NHEJ to HR:
PMID:18001825
SUMOlated PCNA recognizes stalled replication fork and blocks homologous recombination, re-orients toward TLS
PMID:19217833

Confidence
REF=5 FUNC=4


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