Reaction state_transition d_re105

gA_NHEJ_DNA_st1*@Nucleus → gA_NHEJ_DNA_st2*@Nucleus

Reaction regulators:

Catalysis

1. MRE11*:​NBS1*|​S343_pho:​RAD50@default
2. PARP1|​PolyADPribose_unk|​pho@Nucleus
3. ATM|​pho|​S367_pho|​S1893_pho:​CTIP*|​emp:​NBS1*|​S343_pho:​WRN@Nucleus
4. EXO1@default

Inhibition

1. BLM@Nucleus
2. PARP2|​unk|​pho@default
3. Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​PARP3@Nucleus
4. Ku70*:​Ku80*@Nucleus

Modulation

1. PARP1|​PolyADPribose_unk|​pho@Nucleus
2. CTBP*|​S181_pho|​T179_pho|​S185_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho@default

References
PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224
For inhibition of A_NHEJ by DNA-PKs:
PMID:15211575
For stimulation of A_NHEJ by PARP1:
PMID:15498778, PMID:19362533, PMID:24050180
For role of MRN complex in A_NHEJ:
PMID:19654615, PMID:19892829
BLM inhibits A_NHEJ (alt_NHEJ):
PMID:24089143
PMID:24095737

Confidence
REF=5 FUNC=4