Cytochrome_C*

Protein Cytochrome_C* map

Identifiers
cytochrome c, somatic
HUGO:CYCS HGNC:19986 ENTREZ:54205 UNIPROT:P99999 GENECARDS:CYCS REACTOME:53260 KEGG:54205 ATLASONC:GC_CYCS WIKI:CYCS

Maps_Modules
 Apoptosis  map  / CASPASES  map
 Apoptosis  map  / MITOCH_METABOLISM  map
 Survival  map  / PI3K_AKT_MTOR  map

References
synonym:cytochrome_c
PMID:19788417
PMID:16977332

Cytochrome_C*|​ferroheme@Cytoplasm

References
a_re1:( Apoptosis  map ) hierarchical:post-MOMP
a_re482( Apoptosis  map ):
PMID:17377525
review on apoptosome formation
PMID:11864614
stoechiometry apoptosome
PMID:12522243
inhibition of apoptosome formation by prothymosin-alpha
PMID:15087373
in HT-29 colon adenocarcinoma cells, siRNA against ACHE prevents the APAF1:CYCS interaction and etoposide-induced
PMID:14622304
AFP positive influence on apoptosome assembly
PMID:18439902
CAS PHAPI and HSP70 enhance apoptosome formation and caspase activation
a_re483( Apoptosis  map ):
PMID:10980706
PMID:10544189

Cytochrome_C*@Mitochondria

References
s_akt1_re177:( Survival  map ) PMID:20709625

Cytochrome_C*@Cytoplasm

References
s_akt1_re177:( Survival  map ) PMID:20709625
s_akt1_re178( Survival  map ):
PMID:19788417
PMID:16977332


Modifications:
In compartment: Cytoplasm
  1. Cytochrome_C*@Cytoplasm map

  2. Cytochrome_C*|​ferroheme@Cytoplasm map

In compartment: Mitochondria

  1. Cytochrome_C*@Mitochondria map

In compartment: Mitochondrial intermembrane space

  1. Cytochrome_C*@Mitochondrial intermembrane space map

  2. Cytochrome_C*|​ferroheme@Mitochondrial intermembrane space map

Participates in complexes:
In compartment: Cytoplasm

  1. Cytochrome_C*|​ferroheme:​HSPB1@Cytoplasm map

  2. Caspase9*:​Cytochrome_C*:​dATP/ATP@Cytoplasm map
  3. (d)ATP:​APAF1:​Cytochrome_C*|​ferroheme@Cytoplasm map

In compartment: Mitochondrial inner membrane

  1. Cytochrome_C*|​ferriheme:​cardiolipin@Mitochondrial inner membrane map

  2. Cytochrome_C*|​ferroheme:​cardiolipin@Mitochondrial inner membrane map

Participates in reactions:
As Reactant or Product:

  1. Cytochrome_C*|​ferroheme@Mitochondrial intermembrane space map map Cytochrome_C*|​ferroheme@Cytoplasm map

  2. Cytochrome_C*|​ferroheme@Cytoplasm map + (d)ATP@Cytoplasm map + APAF1@Cytoplasm map map (d)ATP:​APAF1:​Cytochrome_C*|​ferroheme@Cytoplasm map
  3. Cytochrome_C*|​ferroheme@Cytoplasm map + HSPB1@Cytoplasm map map Cytochrome_C*|​ferroheme:​HSPB1@Cytoplasm map
  4. Cytochrome_C*|​ferriheme:​cardiolipin@Mitochondrial inner membrane map + H+@Mitochondrial Matrix map + ubiquinol@Mitochondrial inner membrane map map Cytochrome_C*|​ferroheme:​cardiolipin@Mitochondrial inner membrane map + H+@Mitochondrial intermembrane space map + ubiquinone@Mitochondrial inner membrane map
  5. Cytochrome_C*|​ferroheme:​cardiolipin@Mitochondrial inner membrane map + H+@Mitochondrial Matrix map + O_sub_2_endsub_@Mitochondrial inner membrane map map Cytochrome_C*|​ferriheme:​cardiolipin@Mitochondrial inner membrane map + H+@Mitochondrial intermembrane space map
  6. Cytochrome_C*|​ferroheme:​cardiolipin@Mitochondrial inner membrane map + O_sub_2_endsub_@Mitochondrial intermembrane space map map Cytochrome_C*|​ferriheme:​cardiolipin@Mitochondrial inner membrane map + H_sub_2_endsub_O_sub_2_endsub_@Mitochondrial intermembrane space map
  7. Cytochrome_C*@Mitochondrial intermembrane space map + ferroheme b@Mitochondrial intermembrane space map map Cytochrome_C*|​ferroheme@Mitochondrial intermembrane space map
  8. Cytochrome_C*|​ferroheme@Mitochondrial intermembrane space map + cardiolipin@Mitochondrial inner membrane map map Cytochrome_C*|​ferroheme:​cardiolipin@Mitochondrial inner membrane map
  9. Cytochrome_C*|​ferroheme:​cardiolipin@Mitochondrial inner membrane map + H_sub_2_endsub_O_sub_2_endsub_@Mitochondrial intermembrane space map map Cytochrome_C*|​ferroheme@Mitochondrial intermembrane space map + oxidized_cardiolipin@Mitochondrial inner membrane map
  10. rCytochrome_C*@Nucleus map map Cytochrome_C*@Mitochondrial intermembrane space map
  11. Cytochrome_C*@Mitochondria map map Cytochrome_C*@Cytoplasm map
  12. dATP/ATP@Cytoplasm map + s_s_akt1_s718 + Cytochrome_C*@Cytoplasm map map Caspase9*:​Cytochrome_C*:​dATP/ATP@Cytoplasm map

As Catalyser:

  1. Caspase9*@Cytoplasm map map cleaved~Caspase9*@Cytoplasm map

  2. Caspase9*@Cytoplasm map map Caspase9__sub_TRUNC_endsub_*@Cytoplasm map

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