e_re786( EMT ):
Rac1 binds to NCKAP1 and CYFIP2 and also promotes NCK1 binding to NCKAP1.
This binding inhibits NCKAP1 and CYFIP2 binding to WASF1 and promotes release of the complex of WASF1 and BRK1, thus activating WASF1.
Activated WASF1 then stimulates ARP2/3 that mediates actin cytoskeletal polymerizatioin
e_re802( EMT ):
Rac1 stimulates actin polymerization by activation of WAS protein family (WASF1 and WASF2)
In compartment: Cytoplasm
Participates in complexes:
Participates in reactions:
As Reactant or Product: