Protein CYFIP2

Identifiers
cytoplasmic FMR1 interacting protein 2
HUGO:CYFIP2 HGNC:13760 ENTREZ:26999 UNIPROT:Q96F07 GENECARDS:CYFIP2 REACTOME:412747 KEGG:26999 ATLASONC:GC_CYFIP2 WIKI:CYFIP2

Maps_Modules
 EMT   / EMT_REGULATORS 
 EMT   / CYTOSKELETON_POLARITY 

CYFIP2@Cytoplasm

References
e_re786( EMT  ):
PMID:12181570
Rac1 binds to NCKAP1 and CYFIP2 and also promotes NCK1 binding to NCKAP1.
This binding inhibits NCKAP1 and CYFIP2 binding to WASF1 and promotes release of the complex of WASF1 and BRK1, thus activating WASF1.
Activated WASF1 then stimulates ARP2/3 that mediates actin cytoskeletal polymerizatioin
e_re802( EMT  ):
Rac1 stimulates actin polymerization by activation of WAS protein family (WASF1 and WASF2)
PMID:16212495
PMID:9843499
PMID:16702231

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Modifications:
In compartment: Cytoplasm

1. CYFIP2@Cytoplasm

Participates in complexes:

Participates in reactions:
As Reactant or Product:

1. GTP:​RAC1@Cytoplasm → CYFIP2@Cytoplasm

2. CYFIP2@Cytoplasm → BNIP2@Cytoplasm

As Catalyser:

1. WASF1@Cytoplasm → WASF1@Cytoplasm