CyclinD3*

RNA CyclinD3* map

Identifiers
cyclin D3
HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
PMID:21777377
Further studies are required to investigate the mechanism by which Cx31.1 repress cyclin D3 expression

rCyclinD3*@Nucleus

References
e_re673( EMT  map ):
GJB5 is so-called Connexin 31.1
PMID:21777377
Cx31.1 (GJB5) is predominantly expressed in the testes and the skin epidermis.
Cx31.1 rarely form functional gap junction channels, either with itself or with other Cx isoforms.
Gap junctions play important roles in various physiologic functions such as regulation of cell proliferation, cell differentiation, tissue development and cell apoptosis.
In most cases, Cxs act as tumour suppressors: Gap junctions play an important role as tumour suppressors in maintaining cell differentiation and preventing transformation
Cx31.1 reduced tumour cell proliferation, anchorage-independent growth, migration and invasion.
Moreover, development of tumours in a xenograft model was suppressed by Cx31.1, suggesting that Cx31.1 may act as a tumour suppressor in NSCLC cell lines.
Further studies are required to investigate the mechanism by which Cx31.1 repress cyclin D3 expression


Modifications:
In compartment: Nucleus
  1. rCyclinD3*@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. gCyclinD3*@Nucleus map map rCyclinD3*@Nucleus map

    2. rCyclinD3*@Nucleus map map CyclinD3*@Cytoplasm map

    As Catalyser:

      Leave a Reply