CyclinD*

Protein CyclinD* map

Identifiers
Cyclin D1
HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1
Cyclin D2
HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2
Cyclin D3
HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3

Maps_Modules
 DNA repair  map  / G1_CC_PHASE  map
 Cell cycle  map  / CYCLIND  map
 Survival  map  / PI3K_AKT_MTOR  map

References
PMID:20068082, PMID:16236519, PMID:18590585, PMID:19075565, PMID:18786381, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786
PMID:18414028
PMID:19887899

CyclinD*|​Thr286_pho@Cytoplasm

References
c_re244( Cell cycle  map ):
degradation of cyclin D via the ubiquitin-proteasome system
PMID:9736735

CyclinD*@Cytoplasm

References
c_re16:( Cell cycle  map ) PMID:9106657
c_re193:( Cell cycle  map ) PMID:10385618, PMID:10498883, PMID:9106657

CyclinD*|​T286_pho@Nucleus

References
s_akt2_re137:( Survival  map ) PMID:11124803


Modifications:
In compartment: Cytoplasm
  1. CyclinD*@Cytoplasm map

  2. CyclinD*|​Thr286_pho@Cytoplasm map

In compartment: Nucleus

  1. CyclinD*|​T286_pho@Nucleus map

In compartment: default

  1. CyclinD*@default map

  2. CyclinD*|​pho@default map

Participates in complexes:
In compartment: Cytoplasm

  1. CDK6:​CyclinD*@Cytoplasm map

  2. CRM1*:​CyclinD*|​T286_pho@Cytoplasm map
  3. CDK6:​CyclinD*|​Thr286_pho@Cytoplasm map

In compartment: Nucleus

  1. CDK4:​CyclinD*@Nucleus map

  2. CDK6:​CyclinD*@Nucleus map
  3. CRM1*:​CyclinD*|​T286_pho@Nucleus map
  4. CDK4:​CyclinD*|​Thr286_pho@Nucleus map
  5. CDK4:​CyclinD*:​p21CIP1*@Nucleus map
  6. CDK4:​CyclinD*:​p27KIP1*@Nucleus map
  7. CDK6:​CyclinD*:​p21CIP1*@Nucleus map
  8. CDK6:​CyclinD*:​p27KIP1*@Nucleus map
  9. CDK6|​Thr_pho:​CyclinD*:​p27KIP1*@Nucleus map
  10. CDK4|​Thr172_pho:​CyclinD*:​p27KIP1*@Nucleus map
  11. CDK4_6*:​CyclinD*|​T286_pho:​p21CIP1*|​pho|​pho@Nucleus map
  12. CDK4_6*:​CyclinD*|​T286_pho:​p27KIP1*|​pho|​pho|​pho|​S157_pho@Nucleus map

In compartment: default

  1. CDK4_6*:​CyclinD*@default map

  2. CDK4_6*:​CyclinD*|​pho@default map
  3. CDK4_6*|​Y14_pho:​CyclinD*@default map
  4. CDK4_6*|​T172_pho|​Y14_pho:​CyclinD*@default map
  5. (CDK4_6*|​T172_pho:​CyclinD*)|​active@default map
  6. (CDK4_6*:​CIP1_KIP1*:​CyclinD*)|​active@default map

Participates in reactions:
As Reactant or Product:

  1. CDK6@Cytoplasm map + CyclinD*@Cytoplasm map map CDK6:​CyclinD*@Cytoplasm map

  2. CDK6:​CyclinD*:​p27KIP1*@Nucleus map map CDK6|​Thr_pho:​CyclinD*:​p27KIP1*@Nucleus map
  3. CDK4:​CyclinD*:​p27KIP1*@Nucleus map map CDK4|​Thr172_pho:​CyclinD*:​p27KIP1*@Nucleus map
  4. c_s761 map CDK4:​CyclinD*@Nucleus map
  5. CDK6:​CyclinD*@Cytoplasm map map CDK6:​CyclinD*@Nucleus map
  6. p27KIP1*@Nucleus map + CDK4:​CyclinD*@Nucleus map map CDK4:​CyclinD*:​p27KIP1*@Nucleus map
  7. p27KIP1*@Nucleus map + CDK6:​CyclinD*@Nucleus map map CDK6:​CyclinD*:​p27KIP1*@Nucleus map
  8. CDK4:​CyclinD*@Nucleus map map CDK4:​CyclinD*|​Thr286_pho@Nucleus map
  9. CDK4:​CyclinD*|​Thr286_pho@Nucleus map map c_s757
  10. CDK6:​CyclinD*@Nucleus map map CDK6:​CyclinD*|​Thr286_pho@Cytoplasm map
  11. CDK6:​CyclinD*|​Thr286_pho@Cytoplasm map map CDK6:​CyclinD*|​Thr286_pho@Cytoplasm map
  12. CDK4@Cytoplasm map + CyclinD*@Cytoplasm map map c_s761
  13. c_s757 map CyclinD*|​Thr286_pho@Cytoplasm map + CDK4@Cytoplasm map
  14. CDK6:​CyclinD*|​Thr286_pho@Cytoplasm map map CyclinD*|​Thr286_pho@Cytoplasm map + CDK6@Cytoplasm map
  15. CyclinD*|​Thr286_pho@Cytoplasm map map degraded
  16. p21CIP1*@Nucleus map + CDK6:​CyclinD*@Nucleus map map CDK6:​CyclinD*:​p21CIP1*@Nucleus map
  17. p21CIP1*@Nucleus map + CDK4:​CyclinD*@Nucleus map map CDK4:​CyclinD*:​p21CIP1*@Nucleus map
  18. CyclinD*@default map + CDK4_6*@default map map CDK4_6*:​CyclinD*@default map
  19. CyclinD*@default map map degraded
  20. (CDK4_6*|​T172_pho:​CyclinD*)|​active@default map + CIP1_KIP1*@default map map (CDK4_6*:​CIP1_KIP1*:​CyclinD*)|​active@default map
  21. (CDK4_6*:​CIP1_KIP1*:​CyclinD*)|​active@default map map CIP1_KIP1*@default map + (CDK4_6*|​T172_pho:​CyclinD*)|​active@default map
  22. CDK4_6*:​CyclinD*@default map map CDK4_6*|​Y14_pho:​CyclinD*@default map
  23. CDK4_6*|​Y14_pho:​CyclinD*@default map map CDK4_6*|​T172_pho|​Y14_pho:​CyclinD*@default map
  24. CDK4_6*|​T172_pho|​Y14_pho:​CyclinD*@default map map (CDK4_6*|​T172_pho:​CyclinD*)|​active@default map
  25. CDK4_6*:​CyclinD*@default map map CDK4_6*:​CyclinD*|​pho@default map
  26. CDK4_6*:​CyclinD*|​pho@default map map CyclinD*|​pho@default map + CDK4_6*@default map
  27. CyclinD*|​pho@default map map CyclinD*@default map
  28. rCyclinD*@default map map CyclinD*@default map
  29. (CDK4_6*:​p27KIP1*|​pho|​pho|​pho|​S157_pho)|​active@Nucleus map map CDK4_6*:​CyclinD*|​T286_pho:​p27KIP1*|​pho|​pho|​pho|​S157_pho@Nucleus map
  30. CDK4_6*:​CyclinD*|​T286_pho:​p27KIP1*|​pho|​pho|​pho|​S157_pho@Nucleus map map CyclinD*|​T286_pho@Nucleus map + p27KIP1*|​pho|​pho|​pho|​S157_pho@Nucleus map + CDK4_6*@Nucleus map
  31. CyclinD*|​T286_pho@Nucleus map + CRM1*@Nucleus map map CRM1*:​CyclinD*|​T286_pho@Nucleus map
  32. CRM1*:​CyclinD*|​T286_pho@Nucleus map map CRM1*:​CyclinD*|​T286_pho@Cytoplasm map
  33. p21CIP1*|​pho|​pho@Nucleus map + CyclinD*|​T286_pho@Nucleus map + CDK4_6*@Nucleus map map CDK4_6*:​CyclinD*|​T286_pho:​p21CIP1*|​pho|​pho@Nucleus map
  34. CDK4_6*:​CyclinD*|​T286_pho:​p21CIP1*|​pho|​pho@Nucleus map map G1 phase@Nucleus map

As Catalyser:

  1. DP2*:​E2F4:​SIN3B:​SUV39H1:​p130*@Nucleus map map DP2*:​E2F4:​SIN3B:​SUV39H1:​p130*|​pho@Nucleus map

  2. BAF250*:​DP1*:​E2F1:​RB1|​pho@Nucleus map map HDAC1@Nucleus map + BAF250*:​DP1*:​E2F1:​RB1|​pho|​pho@Nucleus map
  3. DP2*:​E2F4:​p107*@Nucleus map map DP2*:​E2F4:​p107*|​pho@Nucleus map
  4. G1 phase@default map map S phase@default map
  5. E2F1:​RB1@default map map E2F1:​RB1|​pho@default map
  6. E2F4_5*:​p107*@default map map E2F4_5*:​p107*|​pho@default map

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