Cu2+:MT-CO2

Complex Cu2+:MT-CO2 map


Complex composition:

  1. MT-CO2 map
  2. Cu2+ map




Cu2+:​MT-CO2@Mitochondrial inner membrane

Identifiers
NAME:Cu2+:MT-CO2

References
a_re1111( Apoptosis  map ):
PMID:15229189
SCO1, SCO2, and COX17 act cooperatively to load MT-CO2 with copper (copper chaperones)
PMID:19393246
in Hela, COX17 siRNA interferes with copper loading into MT-CO2
PMID:18458339
detailed description of COX17 mediated copper loading of SCO proteins, and interactions with the disulfide based modifications of these proteins
a_re93( Apoptosis  map ):
PMID:15119951
SURF1 mutations are associated with Leigh syndrome (cytochrome oxidase deficiency)
PMID:11389896
SURF1 Homolog of Yeast (Shy) is necessary for COX assembly and stability
PMID:19625251
Paroccocus denitrificans SURF1 homologs were proposed to promote heme a insertion into COX subunit 1

Confidence
REF=5 FUNC=0


Modifications:
Participates in complexes:
In compartment: Mitochondrial inner membrane
  1. Cu2+:​MT-CO2@Mitochondrial inner membrane map

Participates in reactions:
As Reactant or Product:

  1. MT-CO2@Mitochondrial inner membrane map + Cu2+@Mitochondrial inner membrane map map Cu2+:​MT-CO2@Mitochondrial inner membrane map

  2. degraded + MT-CO1@Mitochondrial inner membrane map + COX5A@Mitochondrial inner membrane map + COX6A*@Mitochondrial inner membrane map + COX5B@Mitochondrial inner membrane map + COX7A*@Mitochondrial inner membrane map + heme a@Mitochondrial Matrix map + MT-CO3@Mitochondrial inner membrane map + Cu2+:​MT-CO2@Mitochondrial inner membrane map map COX4I1:​COX5A:​COX5B:​COX6A*:​COX6B*:​COX6C:​COX7A*:​COX7B*:​COX7C:​COX8*:​Cu2+:​MT-CO1:​MT-CO2:​MT-CO3:​heme a@Mitochondrial inner membrane map

As Catalyser:

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