CTSB

Protein CTSB map

Identifiers
cathepsin B
HUGO:CTSB HGNC:2527 ENTREZ:1508 UNIPROT:P07858 GENECARDS:CTSB REACTOME:51420 KEGG:1508 ATLASONC:CTSBID40202ch8p23 WIKI:CTSB

Maps_Modules
 Apoptosis  map  / APOPTOSIS_GENES  map
 Apoptosis  map  / MITOCH_METABOLISM  map

References
synonym:cathepsins

CTSB@Mitochondrial intermembrane space

References
a_re723( Apoptosis  map ):
PMID:15775970
AIF as an inner membrane protein that is cleaved and released into the intermembrane space upon apoptosis induction
PMID:15590628
calpain 1 mediated processing
PMID:15933737
cathepsins and calpain 1
PMID:11278689
flavin not necessary for apoptotic function

CTSB@Lysosome

References
a_re1162:( Apoptosis  map ) reactionType:is.a

CTSB|​Modification in lysosome @Lysosome

References
a_re1162:( Apoptosis  map ) reactionType:is.a

CTSB|​Modification in lysosome @Cytoplasm

References
a_re514( Apoptosis  map ):
PMID:11940658
in vitro cleavage of BID by m-calpain
in human metastatic melanoma cell line, 224, in CASP3 deficient MCF-7 breast carcinoma cells, cleavage of BID by calpains and apoptosis in response to cisplatin
use of calpain inhibitors
involvment of mu-calpain cannot be ruled out
PMID:11404357
in rabbit heart mounted onto a Langendorff’s perfusion apparatus, upon ischemia/reperfusion, cleavage of BID by calpains
in vitro cleavage of BID by recombinant mu-calpain
PMID:17264306
in human neutrophils, upon bacteria-induced lysosomal permeabilization, BID cleavage and apoptosis are reversed by cathepsin but not caspase inhibition
PMID:18469004
in different human cell lines (HeLa, MCF-7, SH-SY5Y, HaCaT, CaCo-2,HepG2), upon LeuLeuOMe-induced lysosomal membrane permeabilisation, cleavage of Bid and apoptosis, rescued by E-64d cathepsin inhibitor


Modifications:
In compartment: Cytoplasm
  1. CTSB|​Modification in lysosome @Cytoplasm map

In compartment: Lysosome

  1. CTSB@Lysosome map

  2. CTSB|​Modification in lysosome @Lysosome map

In compartment: Mitochondrial intermembrane space

  1. CTSB@Mitochondrial intermembrane space map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. CTSB@Lysosome map map CTSB|​Modification in lysosome @Lysosome map

    2. CTSB|​Modification in lysosome @Lysosome map map CTSB|​Modification in lysosome @Cytoplasm map
    3. rCTSB@Nucleus map map CTSB@Lysosome map

    As Catalyser:

    1. BID|​unk@Cytoplasm map map cleaved_BID*@Cytoplasm map

    2. AIFM1@Mitochondrial inner membrane map map cleaved~AIFM1*@Mitochondrial intermembrane space map

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