CTIP*:PCNA

Complex CTIP*:PCNA map


Complex composition:

  1. PCNA map
  2. CTIP* map




CTIP*|​emp:​PCNA@default

Identifiers
NAME:CTIP*:PCNA

Maps_Modules
 DNA repair  map  / S_PHASE_CHECKPOINT  map

References
For inhibition of S to G2 propagation and activation of S-phase checkpoint by complex CtIP*/PCNA
PMID:19342888
d_re119( DNA repair  map ):
For inhibition of S-checkpoint by ATM:
PMID:15175241, PMID:12086603
For inhibition of S-checkpoint by HCLK2/FAAP24/ATR/FANKM complex:
PMID:19282663, PMID:19622404, PMID:18995830
For interaction between SNM1B and ATM to mediate S-phase checkpoint in response to ICL (intra-chromatide lesion):
PMID:18469862
Resected DNA is a triger for activating the S-phase checkpoint and moving from G1 to S to G2:
PMID:20051983, PMID:16805667
For inhibition of S to G2 propagation and activation of S-phase checkpoint by complex PCNA:CtIP:
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair. ATR/ATRIP S phase arrest is activated:
PMID:16713580
For role of TIM1*/TIPIN in S-phase checkpoint, stalled replication forks stabilisation and DNA repair during S-phase:
PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221
For inhibition of S-phase by ATR/ATRIP/CHEK1/CLSPN/HCLK2* complex:
PMID:19793801, PMID:17384638
For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint
PMID:15798197
Formation of the complex for crosslink-activation of S phase checkpoint. FA core complex activates the reaction to stop S-phase propagaton:
PMID:14988723, PMID:15136767

Confidence
REF=5 FUNC=5


Modifications:
Participates in complexes:
In compartment: default
  1. CTIP*|​emp:​PCNA@default map

Participates in reactions:
As Reactant or Product:

  1. CTIP*|​emp@default map + PCNA@default map map CTIP*|​emp:​PCNA@default map

As Catalyser:

  1. S phase@default map map G2 phase@default map

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