CTIP*

Protein CTIP* map

Identifiers
retinoblastoma binding protein 8 (RIM)
CTBP-interacting protein (CtIP)
HUGO:RBBP8 HGNC:9891 ENTREZ:5932 UNIPROT:Q99708 GENECARDS:RBBP8 REACTOME:62842 KEGG:5932 ATLASONC:RBBP8ID42066ch18q11 WIKI:RBBP8

Maps_Modules
 DNA repair  map  / G1_S_CHECKPOINT  map
 DNA repair  map  / G2_M_CHECKPOINT  map
 DNA repair  map  / A_NHEJ  map

References
PMID:17965729, PMID:9721205, PMID:19202191, PMID:18171986, PMID:20723763
For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ):
PMID:21376743, PMID:24050180, PMID:22743550

CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho@default

References
d_re110( DNA repair  map ):
Phosphorylation by ATM and ATR at T847, S327
Phosphorylation at S327 by ATM and ATR are essential for shift from A_NHEJ to HR
Phosphorylation by CDC2(CDK1) in cell cycle dep manner to shift from C_NHEJ ot HR at: Ser 267
This phosphorylation allows resection that initiates HR and blocks binding of Ku70/Ku80 complex that initiates C_NHEJ.
PMID:19357644, PMID:15485915, PMID:19490890, PMID:18716619 (for CDK-dep phosph), PMID:20051983
BRCA1 and CtIP interactions make shift from A_NHEJ and C_NHEJ toward HR
Resected DNA in HR is a positive trigger for amplification of the HR pathway (positive loop):
PMID:20051983
Only when CDKs are fully active, this fully activates HR during S and G2 phases:
PMID:18511906, PMID:18716619
d_re118( DNA repair  map ):
BRCA1 ubiquitinates CtIP that allows propagation through G2 to M checkpoint
PMID:16818604
PMID:19357644

CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@default

References
d_re118( DNA repair  map ):
BRCA1 ubiquitinates CtIP that allows propagation through G2 to M checkpoint
PMID:16818604
PMID:19357644
d_re121( DNA repair  map ):
The shift from C_NHEJ to HR is regulated by the CtIP and BRCA1. CDK1-dependent phosphorylation of CtIP regulates the shift: PMID:19357644
PMID:15485915

CTIP*|​ubi@default

References
d_re111:( DNA repair  map ) PMID:14654780

CTIP*|​emp@default

References
d_re110( DNA repair  map ):
Phosphorylation by ATM and ATR at T847, S327
Phosphorylation at S327 by ATM and ATR are essential for shift from A_NHEJ to HR
Phosphorylation by CDC2(CDK1) in cell cycle dep manner to shift from C_NHEJ ot HR at: Ser 267
This phosphorylation allows resection that initiates HR and blocks binding of Ku70/Ku80 complex that initiates C_NHEJ.
PMID:19357644, PMID:15485915, PMID:19490890, PMID:18716619 (for CDK-dep phosph), PMID:20051983
BRCA1 and CtIP interactions make shift from A_NHEJ and C_NHEJ toward HR
Resected DNA in HR is a positive trigger for amplification of the HR pathway (positive loop):
PMID:20051983
Only when CDKs are fully active, this fully activates HR during S and G2 phases:
PMID:18511906, PMID:18716619
d_re111:( DNA repair  map ) PMID:14654780
d_re122( DNA repair  map ):
PMID:20064462,
MRN complex in A_NHEJ: PMID:19362533, PMID:19654615, PMID:19892829


Modifications:
In compartment: default
  1. CTIP*|​emp@default map

  2. CTIP*|​ubi@default map
  3. CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho@default map
  4. CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@default map

Participates in complexes:
In compartment: Nucleus

  1. ATM|​pho|​S367_pho|​S1893_pho:​CTIP*|​emp:​NBS1*|​S343_pho:​WRN@Nucleus map

In compartment: default

  1. CTIP*|​emp:​PCNA@default map

  2. CTBP*|​S181_pho|​T179_pho|​S185_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho@default map
  3. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@default map
  4. CTBP*|​S181_pho|​T179_pho|​S185_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho:​RB1@default map
  5. BRCA1:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi:​MRE11*:​NBS1*|​S343_pho:​PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho:​RAD50@default map

Participates in reactions:
As Reactant or Product:

  1. CTBP*|​S181_pho|​T179_pho|​S185_pho@default map + CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho@default map map CTBP*|​S181_pho|​T179_pho|​S185_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho@default map

  2. CTIP*|​emp@default map map CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho@default map
  3. CTIP*|​emp@default map map CTIP*|​ubi@default map
  4. CTIP*|​ubi@default map map degraded
  5. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@default map + MRE11*:​NBS1*|​S343_pho:​RAD50@default map + PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho@default map map BRCA1:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi:​MRE11*:​NBS1*|​S343_pho:​PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho:​RAD50@default map
  6. CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho@default map map CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@default map
  7. CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@default map + BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default map map BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@default map
  8. ATM|​pho|​S367_pho|​S1893_pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@default map + CTIP*|​emp@default map + WRN@Nucleus map map ATM|​pho|​S367_pho|​S1893_pho:​CTIP*|​emp:​NBS1*|​S343_pho:​WRN@Nucleus map
  9. CTIP*|​emp@default map + PCNA@default map map CTIP*|​emp:​PCNA@default map
  10. CTBP*|​S181_pho|​T179_pho|​S185_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho@default map + RB1@default map map CTBP*|​S181_pho|​T179_pho|​S185_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho:​RB1@default map

As Catalyser:

  1. gA_NHEJ_DNA_st1*@Nucleus map map gA_NHEJ_DNA_st2*@Nucleus map

  2. gHR_DNA_st1*@Nucleus map map gHR_DNA_st2*@Nucleus map
  3. G1 phase@default map map S phase@default map
  4. S phase@default map map G2 phase@default map
  5. G2 phase@default map map M phase@default map
  6. CHEK1@default map map CHEK1|​pho|​active@default map
  7. gC_NHEJ_DNA_st1*@Nucleus map map gC_NHEJ_DNA_st2*@Nucleus map

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