CTBP1_2*:HDAC1:HDAC3:SNAI2

Complex CTBP1_2*:HDAC1:HDAC3:SNAI2 map


Complex composition:

  1. CTBP1_2* map
  2. HDAC1 map
  3. HDAC3 map
  4. SNAI2 map




CTBP1_2*:​HDAC1:​HDAC3:​SNAI2@Nucleus

Identifiers
NAME:CTBP1_2*:HDAC1:HDAC3:SNAI2

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
PMID:17508028
e_re275( EMT  map ):
PMID:9618481
-Smad4 transactivated the proximal p21 promoter 1.3-fold
-Smad2 transactivated the proximal p21 promoter 3-fold
-Smad2/4 transactivated the proximal p21 promoter 12-fold
-Smad3 transactivated the proximal p21 promoter 25-fold
-Smad3/Smad2 transactivated the proximal p21 promoter 40-fold
-Smad3/Smad4 transactivated the proximal p21 promoter 110-fold
-Smad2/Smad3/Smad4 transactivated the proximal p21 promoter 140-fold
Smad proteins act as Transcriptional Activators via functional interactions with the Transcription factor Sp1
PMID:12545156
Myc represses differentiation-induced p21 expression via Miz-1-dependent interaction with the p21 core promoter
Myc binds the p21 core promoter in vitro through interaction with Miz-1
Myc and Miz-1 interact with the p21 promoter in vivo
PMID:15155580
Snail regulates cell-cycle progression and survival:
Snail regulates components of the early to late G1 transition and the G1/S checkpoint.
Snail represses Cyclin D2 transcription and increases p21/Cip1 transcription.
PMID:17550342
SNAI2 induces p21CIP1 (CDKN1A) expression
e_re523( EMT  map ):
PMID:12668723
Snail binds directly to the E-boxes of the promoters of claudin et occludin genes, resulting in complete repression of their promoter activity
PMID:16232121
Snail and Slug bind to the E-box motifs present in the human Claudin-1 promoter.
High levels of Snail and Slug correlatedwith lowlevels of Claudin-1 expression.
It is proposed that Claudin-1 is a direct downstream target gene of Snail family factors in epithelial cells
PMID:15151915
The transcription factors B-catenin/Tcf complex has been shown to bind directly to the claudin-1 and claudin-2 promoters.
SNAI2 represses Claudin-1 expression
SNAI1 represses Claudin-1 expression
e_re1197( EMT  map ):
PMID:21919891
PMID:21733352
Direct activation of Bmi1 expression by Twist1 using transient transfection.
PMID:20818389
Twist1 directly activates BMI1 transcription by binding to the E-box in intron 1 of the BMI1 gene.
SNAI2 induces BMI1 expression
e_re1293( EMT  map ):
SNAI2 represses MDM2 expression, thus skip p53 from proteasomal degradation
e_re1295( EMT  map ):
SNAI2 induces HDAC1 expression
e_re1297( EMT  map ):
SNAI2 induces HDAC2 expression
e_re1299( EMT  map ):
SNAI2 induces SIN3A expression

Confidence
REF=5 FUNC=4


Modifications:
Participates in complexes:
In compartment: Nucleus
  1. CTBP1_2*:​HDAC1:​HDAC3:​SNAI2@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. SNAI2@Nucleus map + CTBP1_2*@Nucleus map + HDAC1@Nucleus map + HDAC3@Nucleus map map CTBP1_2*:​HDAC1:​HDAC3:​SNAI2@Nucleus map

As Catalyser:

  1. gBMI1@Nucleus map map rBMI1@Nucleus map

  2. gMDM2@Nucleus map map rMDM2@Nucleus map
  3. gHDAC1@Nucleus map map rHDAC1@Nucleus map
  4. gHDAC2@Nucleus map map rHDAC2@Nucleus map
  5. gSIN3A@Nucleus map map rSIN3A@Nucleus map
  6. gp21CIP1*@Nucleus map map rp21CIP1*@Nucleus map
  7. gE-Cadherin*@Nucleus map map rE-Cadherin*@Nucleus map
  8. gClaudin1*@Nucleus map map rClaudin1*@Nucleus map

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