e_re275( EMT ):
-Smad4 transactivated the proximal p21 promoter 1.3-fold
-Smad2 transactivated the proximal p21 promoter 3-fold
-Smad2/4 transactivated the proximal p21 promoter 12-fold
-Smad3 transactivated the proximal p21 promoter 25-fold
-Smad3/Smad2 transactivated the proximal p21 promoter 40-fold
-Smad3/Smad4 transactivated the proximal p21 promoter 110-fold
-Smad2/Smad3/Smad4 transactivated the proximal p21 promoter 140-fold
Smad proteins act as Transcriptional Activators via functional interactions with the Transcription factor Sp1
Myc represses differentiation-induced p21 expression via Miz-1-dependent interaction with the p21 core promoter
Myc binds the p21 core promoter in vitro through interaction with Miz-1
Myc and Miz-1 interact with the p21 promoter in vivo
Snail regulates cell-cycle progression and survival:
Snail regulates components of the early to late G1 transition and the G1/S checkpoint.
Snail represses Cyclin D2 transcription and increases p21/Cip1 transcription.
SNAI2 induces p21CIP1 (CDKN1A) expression
e_re523( EMT ):
Snail binds directly to the E-boxes of the promoters of claudin et occludin genes, resulting in complete repression of their promoter activity
Snail and Slug bind to the E-box motifs present in the human Claudin-1 promoter.
High levels of Snail and Slug correlatedwith lowlevels of Claudin-1 expression.
It is proposed that Claudin-1 is a direct downstream target gene of Snail family factors in epithelial cells
The transcription factors B-catenin/Tcf complex has been shown to bind directly to the claudin-1 and claudin-2 promoters.
SNAI2 represses Claudin-1 expression
SNAI1 represses Claudin-1 expression
e_re1197( EMT ):
Direct activation of Bmi1 expression by Twist1 using transient transfection.
Twist1 directly activates BMI1 transcription by binding to the E-box in intron 1 of the BMI1 gene.
SNAI2 induces BMI1 expression
e_re1293( EMT ):
SNAI2 represses MDM2 expression, thus skip p53 from proteasomal degradation
e_re1295( EMT ):
SNAI2 induces HDAC1 expression
e_re1297( EMT ):
SNAI2 induces HDAC2 expression
e_re1299( EMT ):
SNAI2 induces SIN3A expression
Participates in complexes:
In compartment: Nucleus
Participates in reactions:
As Reactant or Product:
- SNAI2@Nucleus + CTBP1_2*@Nucleus + HDAC1@Nucleus + HDAC3@Nucleus → CTBP1_2*:HDAC1:HDAC3:SNAI2@Nucleus