CTBP*

Protein CTBP* map

Identifiers
C-terminal binding protein 1
HUGO:CTBP1 HGNC:2494 ENTREZ:1487 UNIPROT:Q13363 GENECARDS:CTBP1 KEGG:1487 ATLASONC:GC_CTBP1 WIKI:CTBP1
C-terminal binding protein 2
HUGO:CTBP2 HGNC:2495 ENTREZ:1488 UNIPROT:P56545 GENECARDS:CTBP2 ATLASONC:GC_CTBP2 WIKI:CTBP2

Maps_Modules
 Apoptosis  map  / APOPTOSIS_GENES  map
 DNA repair  map  / G1_S_CHECKPOINT  map
 DNA repair  map  / G2_M_CHECKPOINT  map
 Survival  map  / WNT_CANONICAL  map

References
PMID:21681822, PMID:20964627, PMID:19506021, PMID:19216735

CTBP*@Nucleus

References
a_re458:( Apoptosis  map ) reactionType:is.a
a_re126( Apoptosis  map ):
PMID:14699081
in Saos-2, direct transactivation of NOXA by HIF1A during hypoxia, role of NOXA in hypoxia-induced cell death
PMID:16888645
in SH-EP, in NB15 neuroblastoma cell lines expressing a FOXO3-ER fusion, upon 4OHT. PMAIP knock down protects from apoptosis
PMID:12676992
in MEF by CTBP1 and CTBP2 (RT-PCR, double knocked out)
PMID:14684737
in NIH3T3, by E2F1
a_re134( Apoptosis  map ):
PMID:7834749
by p53
PMID:15613549
in HEK 293, by NFkB, upon expression of LMP1 protein (from EBV). More precisely, p65/p50 dimer inhibits BAX promoter activity whereas p50/p50 dimer is actually an transcriptional activator or BAX. However p65 has to be inhibited to see p50/p50 mediated activation of BAX
in MEF double knocked out by CTBP1 and CTBP2 (RT-PCR)
a_re136( Apoptosis  map ):
PMID:8242752
by TP53
a_re449:( Apoptosis  map ) PMID:16508011
a_re450( Apoptosis  map ):
PMID:15708980
in H1299 by HIPK2 upon UV
PMID:16984892
in vitro
in H1299 upon JNK1 sustained activation (ectopic expression, UV or cisPlatin, in COS7), by JNK
in MEFs upon UV, but not in JNK1 KO MEFs

CTBP*|​S422_pho@Nucleus

References
a_re450( Apoptosis  map ):
PMID:15708980
in H1299 by HIPK2 upon UV
PMID:16984892
in vitro
in H1299 upon JNK1 sustained activation (ectopic expression, UV or cisPlatin, in COS7), by JNK
in MEFs upon UV, but not in JNK1 KO MEFs
a_re451( Apoptosis  map ):
in MEFs upon cisPlatin, reversed by JNK1 KO

CTBP*|​S181_pho|​T179_pho|​S185_pho@default

References
d_re408:( DNA repair  map ) PMID:9858600

CTBP*|​pho@default

References
d_re59:( DNA repair  map ) PMID:19788416

CTBP*@default

References
d_re59:( DNA repair  map ) PMID:19788416
d_re408:( DNA repair  map ) PMID:9858600

CTBP*|​hm2@Nucleus

References
s_wca3_re105:( Survival  map ) PMID:15037661
s_wca3_re104:( Survival  map ) PMID:15525529


Modifications:
In compartment: Nucleus
  1. CTBP*@Nucleus map

  2. CTBP*|​hm2@Nucleus map
  3. CTBP*|​S422_pho@Nucleus map

In compartment: default

  1. CTBP*@default map

  2. CTBP*|​pho@default map
  3. CTBP*|​S181_pho|​T179_pho|​S185_pho@default map

Participates in complexes:
In compartment: Nucleus

  1. CTBP*:​p300*@Nucleus map

  2. APC:​CTBP*|​hm2@Nucleus map
  3. CTBP*:​KLF8|​K67_unk@Nucleus map
  4. CTBP*:​HIPK2:​LEF_TCF*@Nucleus map
  5. APC:​CTBP*|​hm2:​HDAC1_2*@Nucleus map
  6. APC|​T1487_pho:​CTBP*|​hm2:​HDAC1_2*@Nucleus map
  7. CTBP*:​HDAC1_2*:​LEF_TCF*:​WRE*@Nucleus map
  8. BCL9:​CTBP*:​KLF4:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​ace@Nucleus map
  9. APC|​T1487_pho:​BCL9:​CTBP*|​hm2:​DVL*:​HDAC1_2*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map

In compartment: default

  1. CTBP*|​S181_pho|​T179_pho|​S185_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho@default map

  2. CTBP*|​S181_pho|​T179_pho|​S185_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho:​RB1@default map

Participates in reactions:
As Reactant or Product:

  1. CTBP1@Nucleus map map CTBP*@Nucleus map

  2. CTBP*@Nucleus map map degraded
  3. CTBP*@Nucleus map map CTBP*|​S422_pho@Nucleus map
  4. CTBP*|​S422_pho@Nucleus map map degraded
  5. CTBP2@Nucleus map map CTBP*@Nucleus map
  6. CTBP*|​S181_pho|​T179_pho|​S185_pho@default map + CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho@default map map CTBP*|​S181_pho|​T179_pho|​S185_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho@default map
  7. CTBP*@default map map CTBP*|​S181_pho|​T179_pho|​S185_pho@default map
  8. CTBP*|​S181_pho|​T179_pho|​S185_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho@default map + RB1@default map map CTBP*|​S181_pho|​T179_pho|​S185_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho:​RB1@default map
  9. CTBP*@default map map CTBP*|​pho@default map
  10. CTBP*|​pho@default map map degraded
  11. APC@Nucleus map + CTBP*|​hm2@Nucleus map map APC:​CTBP*|​hm2@Nucleus map
  12. CTBP*@Nucleus map map CTBP*|​hm2@Nucleus map
  13. HDAC1_2*@Nucleus map + APC:​CTBP*|​hm2@Nucleus map map APC:​CTBP*|​hm2:​HDAC1_2*@Nucleus map
  14. APC:​CTBP*|​hm2:​HDAC1_2*@Nucleus map map APC|​T1487_pho:​CTBP*|​hm2:​HDAC1_2*@Nucleus map
  15. APC|​T1487_pho:​CTBP*|​hm2:​HDAC1_2*@Nucleus map + BCL9:​DVL*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map map APC|​T1487_pho:​BCL9:​CTBP*|​hm2:​DVL*:​HDAC1_2*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map
  16. APC|​T1487_pho:​BCL9:​CTBP*|​hm2:​DVL*:​HDAC1_2*:​JUN|​pho|​pho:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​K345_ace|​ace:​p300*@Nucleus map map APC|​T1487_pho:​_beta_-Catenin*|​K345_ace|​ace@Nucleus map + CTBP*:​p300*@Nucleus map + CTBP*:​HDAC1_2*:​LEF_TCF*:​WRE*@Nucleus map + DVL*:​JUN|​pho|​pho@Nucleus map
  17. CTBP*:​HDAC1_2*:​LEF_TCF*:​WRE*@Nucleus map + TLE*@Nucleus map map CTBP*@Nucleus map + HDAC1_2*:​LEF_TCF*:​TLE*:​WRE*@Nucleus map
  18. KLF8@Nucleus map + CTBP*@Nucleus map map s_s_wca3_s454
  19. s_s_wca3_s454 map CTBP*:​KLF8|​K67_unk@Nucleus map
  20. KLF4@Nucleus map + BCL9:​PYGO*:​_beta_-Catenin*|​ace@Nucleus map + LEF_TCF*@Nucleus map + CTBP*@Nucleus map + gWRE*@Nucleus map map BCL9:​CTBP*:​KLF4:​LEF_TCF*:​PYGO*:​WRE*:​_beta_-Catenin*|​ace@Nucleus map
  21. CTBP*@Nucleus map map CTBP*|​S422_pho@Nucleus map
  22. CTBP*|​S422_pho@Nucleus map map degraded
  23. _beta_-Catenin*@Nucleus map + HIPK2@Nucleus map + CTBP*@Nucleus map + LEF_TCF*@Nucleus map map CTBP*:​HIPK2:​LEF_TCF*@Nucleus map

As Catalyser:

  1. gPMAIP1@Nucleus map map rPMAIP1@Nucleus map

  2. gBAX@Nucleus map map rBAX@Nucleus map
  3. gp21CIP1*@Nucleus map map rp21CIP1*@Nucleus map
  4. gA_NHEJ_DNA_st1*@Nucleus map map gA_NHEJ_DNA_st2*@Nucleus map
  5. G1 phase@default map map S phase@default map
  6. gKLF4@Nucleus map map rKLF4@Nucleus map
  7. gCyclinD*@Nucleus map map rCyclinD*@Nucleus map
  8. gE-Cadherin*@Nucleus map map rE-Cadherin*@Nucleus map
  9. gGenes under control of _br_CBP-mediated transcription*@Nucleus map map rRNA@Nucleus map
  10. gGene under control of_br_ P300-mediated transcription*@Nucleus map map rRNA@Nucleus map

Leave a Reply