CRK

Protein CRK map

Identifiers
v-crk sarcoma virus CT10 oncogene homolog (avian)
“v-crk avian sarcoma virus CT10 oncogene homolog”
HUGO:CRK HGNC:2362 ENTREZ:1398 UNIPROT:P46108 GENECARDS:CRK REACTOME:404090 KEGG:1398 ATLASONC:CRKID40149ch17p13 WIKI:CRK

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CELL_MATRIX_ADHESIONS  map

References
PMID:16000375
Src and FAK kinases cooperate to phosphorylate paxillin, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness.
Phosphorylated paxillin binding to Crk is implicated in Rac activation and stimulation of cell motility
PMID:15308668
CRK bound to DOCK1 (so-called DOCK180) forms complex with phosphorylated paxillin.
The complex is necessary for collagen-dependent cell migration, mainly through Rac1 activation.

CRK@Cytoplasm

References
e_re981( EMT  map ):
PMID:16000375
Src and FAK kinases cooperate to phosphorylate paxillin, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness.
Phosphorylated paxillin binding to Crk is implicated in Rac activation and stimulation of cell motility
PMID:15308668
CRK bound to DOCK1 (so-called DOCK180) forms complex with phosphorylated paxillin.
The complex is necessary for collagen-dependent cell migration, mainly through Rac1 activation.


Modifications:
In compartment: Cytoplasm
  1. CRK@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. CRK:​DOCK1:​PXN|​pho@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. PXN|​pho@Cytoplasm map + CRK@Cytoplasm map + DOCK1@Cytoplasm map map CRK:​DOCK1:​PXN|​pho@Cytoplasm map

  2. CRK:​DOCK1:​PXN|​pho@Cytoplasm map map Membrane spreading@Cytoplasm map

As Catalyser:

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