CRB3

Protein CRB3 map

Identifiers
crumbs homolog 3 (Drosophila)
HUGO:CRB3 HGNC:20237 ENTREZ:92359 UNIPROT:Q9BUF7 GENECARDS:CRB3 REACTOME:225622 WIKI:CRB3

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

References
PMID:22881460
CRB3 is the only transmembrane protein among apical polarity regulators
PMID:2344615
Link between Drosophila apical membrane Crb and epithelia organization

CRB3@Cytoplasm

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

References
PMID:22881460
CRB3 is the only transmembrane protein among apical polarity regulators
PMID:2344615
Link between Drosophila apical membrane Crb and epithelia organization
e_re113( EMT  map ):
PMID:2288140
PMID:8365569
Without PALS1 (Sdt in Drosophila), CRB is delivered to the apical plasma membrane but rapidly endocytosed and degraded
The complex PALS1-CRB hence stabilizes CRB
e_re95( EMT  map ):
PMID:18005931
PMID:11740559
PMID:11740560
CRB3 and PALS1* in the same pathway
PALS1* binds to CRB3 via its PDZ domain


Modifications:
In compartment: Cytoplasm
  1. CRB3@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. CRB3:​PALS1*@Cytoplasm map

  2. CRB3:​LIN7C:​PALS1*:​PATJ*@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. CRB3:​PALS1*@Cytoplasm map map CRB3@Cytoplasm map

  2. CRB3:​LIN7C:​PALS1*:​PATJ*@Cytoplasm map map PALS1*@Cytoplasm map
  3. PATJ*@Cytoplasm map map CRB3:​LIN7C:​PALS1*:​PATJ*@Cytoplasm map
  4. rCRB3@Nucleus map map CRB3@Cytoplasm map
  5. CRB3:​LIN7C:​PALS1*:​PATJ*@Cytoplasm map map Establishment of cell polarity@Nucleus map
  6. CRB3:​LIN7C:​PALS1*:​PATJ*@Cytoplasm map map Tight junctions@Extracellular space map
  7. CRB3@Cytoplasm map map degraded
  8. CRB3@Cytoplasm map map degraded
  9. CRB3@Cytoplasm map + PALS1*@Cytoplasm map map CRB3:​PALS1*@Cytoplasm map
  10. PATJ*@Cytoplasm map + CRB3:​PALS1*@Cytoplasm map + LIN7C@Cytoplasm map map CRB3:​LIN7C:​PALS1*:​PATJ*@Cytoplasm map

As Catalyser:

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