COX4I2

Protein COX4I2 map

Identifiers
cytochrome c oxidase subunit IV isoform 2 (lung)
HUGO:COX4I2 HGNC:16232 ENTREZ:84701 UNIPROT:Q96KJ9 GENECARDS:COX4I2 KEGG:84701 ATLASONC:GC_COX4I2 WIKI:COX4I2

Maps_Modules
 Apoptosis  map  / APOPTOSIS_GENES  map
 Apoptosis  map  / MITOCH_METABOLISM  map

COX4I2@Mitochondrial inner membrane

References
a_re92( Apoptosis  map ):
PMID:17418790
Upon hypoxia, COX4I1 degraded by LONP1 is replaced into the COX complex by COX4I2, resulting in lower ROS generation and higher electron transport chain activity


Modifications:
In compartment: Mitochondrial inner membrane
  1. COX4I2@Mitochondrial inner membrane map

Participates in complexes:
In compartment: Mitochondrial inner membrane

  1. COX4I2:​COX5A:​COX5B:​COX6A*:​COX6B*:​COX6C:​COX7A*:​COX7B*:​COX7C:​COX8*:​Cu2+:​MT-CO1:​MT-CO2:​MT-CO3:​heme a@Mitochondrial inner membrane map

Participates in reactions:
As Reactant or Product:

  1. rCOX4I2@Nucleus map map COX4I2@Mitochondrial inner membrane map

  2. COX4I1:​COX5A:​COX5B:​COX6A*:​COX6B*:​COX6C:​COX7A*:​COX7B*:​COX7C:​COX8*:​Cu2+:​MT-CO1:​MT-CO2:​MT-CO3:​heme a@Mitochondrial inner membrane map + COX4I2@Mitochondrial inner membrane map + ATP@Mitochondrial Matrix map map COX4I2:​COX5A:​COX5B:​COX6A*:​COX6B*:​COX6C:​COX7A*:​COX7B*:​COX7C:​COX8*:​Cu2+:​MT-CO1:​MT-CO2:​MT-CO3:​heme a@Mitochondrial inner membrane map + ADP@Mitochondrial Matrix map

As Catalyser:

  1. Cytochrome_C*|​ferroheme:​cardiolipin@Mitochondrial inner membrane map + H+@Mitochondrial Matrix map + O_sub_2_endsub_@Mitochondrial inner membrane map map Cytochrome_C*|​ferriheme:​cardiolipin@Mitochondrial inner membrane map + H+@Mitochondrial intermembrane space map

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