COX4I1:COX5A:COX5B:COX6A*:COX6B*:COX6C:COX7A*:COX7B*:COX7C:COX8*:Cu2+:MT-CO1:MT-CO2:MT-CO3:heme a

Complex COX4I1:COX5A:COX5B:COX6A*:COX6B*:COX6C:COX7A*:COX7B*:COX7C:COX8*:Cu2+:MT-CO1:MT-CO2:MT-CO3:heme a map


Complex composition:

  1. COX4I1 map
  2. MT-CO1 map
  3. MT-CO3 map
  4. COX5A map
  5. COX5B map
  6. COX6C map
  7. COX7C map
  8. COX6A* map
  9. COX6B* map
  10. COX7A* map
  11. COX7B* map
  12. COX8* map
  13. heme a map
  14. MT-CO2 map
  15. Cu2+ map




COX4I1:​COX5A:​COX5B:​COX6A*:​COX6B*:​COX6C:​COX7A*:​COX7B*:​COX7C:​COX8*:​Cu2+:​MT-CO1:​MT-CO2:​MT-CO3:​heme a@Mitochondrial inner membrane

Identifiers
NAME:COX4I1:COX5A:COX5B:COX6A*:COX6B*:COX6C:COX7A*:COX7B*:COX7C:COX8*:Cu2+:MT-CO1:MT-CO2:MT-CO3:heme a

References
stoechiometry:FALSE
a_re93( Apoptosis  map ):
PMID:15119951
SURF1 mutations are associated with Leigh syndrome (cytochrome oxidase deficiency)
PMID:11389896
SURF1 Homolog of Yeast (Shy) is necessary for COX assembly and stability
PMID:19625251
Paroccocus denitrificans SURF1 homologs were proposed to promote heme a insertion into COX subunit 1
a_re90( Apoptosis  map ):
PMID:8194600
cytochrome oxidase inhibition by nitric oxide
a_re91( Apoptosis  map ):
PMID:16051147
in mice p66Shc couples O2 reduction to CYCS oxidation
a_re92( Apoptosis  map ):
PMID:17418790
Upon hypoxia, COX4I1 degraded by LONP1 is replaced into the COX complex by COX4I2, resulting in lower ROS generation and higher electron transport chain activity

Confidence
REF=5 FUNC=3


Modifications:
Participates in complexes:
In compartment: Mitochondrial inner membrane
  1. COX4I1:​COX5A:​COX5B:​COX6A*:​COX6B*:​COX6C:​COX7A*:​COX7B*:​COX7C:​COX8*:​Cu2+:​MT-CO1:​MT-CO2:​MT-CO3:​heme a@Mitochondrial inner membrane map

Participates in reactions:
As Reactant or Product:

  1. COX4I1:​COX5A:​COX5B:​COX6A*:​COX6B*:​COX6C:​COX7A*:​COX7B*:​COX7C:​COX8*:​Cu2+:​MT-CO1:​MT-CO2:​MT-CO3:​heme a@Mitochondrial inner membrane map + COX4I2@Mitochondrial inner membrane map + ATP@Mitochondrial Matrix map map COX4I2:​COX5A:​COX5B:​COX6A*:​COX6B*:​COX6C:​COX7A*:​COX7B*:​COX7C:​COX8*:​Cu2+:​MT-CO1:​MT-CO2:​MT-CO3:​heme a@Mitochondrial inner membrane map + ADP@Mitochondrial Matrix map

  2. degraded + MT-CO1@Mitochondrial inner membrane map + COX5A@Mitochondrial inner membrane map + COX6A*@Mitochondrial inner membrane map + COX5B@Mitochondrial inner membrane map + COX7A*@Mitochondrial inner membrane map + heme a@Mitochondrial Matrix map + MT-CO3@Mitochondrial inner membrane map + Cu2+:​MT-CO2@Mitochondrial inner membrane map map COX4I1:​COX5A:​COX5B:​COX6A*:​COX6B*:​COX6C:​COX7A*:​COX7B*:​COX7C:​COX8*:​Cu2+:​MT-CO1:​MT-CO2:​MT-CO3:​heme a@Mitochondrial inner membrane map

As Catalyser:

  1. Cytochrome_C*|​ferroheme:​cardiolipin@Mitochondrial inner membrane map + H+@Mitochondrial Matrix map + O_sub_2_endsub_@Mitochondrial inner membrane map map Cytochrome_C*|​ferriheme:​cardiolipin@Mitochondrial inner membrane map + H+@Mitochondrial intermembrane space map

  2. Cytochrome_C*|​ferroheme:​cardiolipin@Mitochondrial inner membrane map + O_sub_2_endsub_@Mitochondrial intermembrane space map map Cytochrome_C*|​ferriheme:​cardiolipin@Mitochondrial inner membrane map + H_sub_2_endsub_O_sub_2_endsub_@Mitochondrial intermembrane space map

Leave a Reply