Collagen1*

Protein Collagen1* map

Identifiers
Collagen 1*
collagen, type I, alpha 1
HUGO:COL1A1 HGNC:2197 ENTREZ:1277 UNIPROT:P02452 GENECARDS:COL1A1 REACTOME:51126 KEGG:1277 ATLASONC:COL1A1ID186 WIKI:COL1A1
collagen, type I, alpha 2
HUGO:COL1A2 HGNC:2198 ENTREZ:1278 UNIPROT:P08123 GENECARDS:COL1A2 REACTOME:51158 KEGG:1278 ATLASONC:COL1A2ID411ch7q22 WIKI:COL1A2

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CELL_MATRIX_ADHESIONS  map
 EMT  map  / ECM  map

References
PMID:18375391
Type I procollagen is a heterotrimer composed of 2 proalpha1(I) chains (encoded by COL1A1) and 1 proalpha2(I) chain (encoded by COL1A2 genes)
proalpha2(I) C-propeptide and proalpha1(I) C-propeptide, is essential for efficient assembly of type I procollagen heterotrimers.
PMID:17217948
Inhibition of RhoA/Rho-kinase pathway suppresses the expression of type I collagen induced by TGFB2 in human retinal pigment epithelial cells
PMID:11114293
Sp1 and Smad proteins form complexes and their synergy plays an important role in mediating TGFB1-induced 2(I) collagen expression in human mesangial cells.
Involvement of Sp1 binding in Smad3-mediated TGFB1 induction of COL1A2
Sp1 and Smad proteins bind to the COL1A2 promoter
TGFB1 increases association between Sp1 and Smad proteins
Sp1 and Smad3 cooperate to regulate COL1A2 expression

Collagen1*@Extracellular space

References
e_re904( EMT  map ):
PMID:19161977
In the endoplasmic reticulum, integrin subunits find their binding partners and form heterodimers.
Monomeric integrins never reach the cell surface.
Integrins a1b1, a2b1, a10b1 and a11b1 bind to collagens


Modifications:
In compartment: Extracellular space
  1. Collagen1*@Extracellular space map

Participates in complexes:
In compartment: Extracellular space

  1. Collagen1*:​a1b1*_a2b1*@Extracellular space map

  2. Collagen1 partners*:​Collagen1*@Extracellular space map

Participates in reactions:
As Reactant or Product:

  1. Collagen1*@Extracellular space map + Collagen1 partners*@Extracellular space map map Collagen1 partners*:​Collagen1*@Extracellular space map

  2. Collagen1 partners*:​Collagen1*@Extracellular space map map Cell-matrix adhesions@Extracellular space map
  3. Collagen1*@Extracellular space map map Truncated Collagen1*@Extracellular space map
  4. Collagen1*@Extracellular space map map COL1A2@Extracellular space map
  5. Collagen1*@Extracellular space map map COL1A1@Cytoplasm map
  6. a1b1*_a2b1*@Extracellular space map + Collagen1*@Extracellular space map map Collagen1*:​a1b1*_a2b1*@Extracellular space map
  7. Collagen1*:​a1b1*_a2b1*@Extracellular space map map Cell-matrix adhesions@Extracellular space map

As Catalyser:

    Leave a Reply