COL4A1

Protein COL4A1 map

Identifiers
collagen, type IV, alpha 1
HUGO:COL4A1 HGNC:2202 ENTREZ:1282 UNIPROT:P02462 GENECARDS:COL4A1 REACTOME:51132 KEGG:1282 ATLASONC:GC_COL4A1 WIKI:COL4A1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CELL_MATRIX_ADHESIONS  map
 EMT  map  / ECM  map

COL4A1@Cytoplasm

References
e_re907( EMT  map ):
PMID:19161977
In the endoplasmic reticulum, integrin subunits find their binding partners and form heterodimers.
Monomeric integrins never reach the cell surface.
Integrins a1b1, a2b1, a10b1 and a11b1 bind to collagens
PMID:12297042
Cell adhesion to components of the ECM is important in the angiogenesis
PMID:2153105
PMID:2786007
PMID:7639691
PMID:10809728
integrins are receptors for different ECM proteins: Collagen 1, 4; Laminin 1, 8; Fibronectin and Vitronectin
PMID:7522194
PMID:16195317
Interactions between integrins and the ECM proteins result in focal cell adhesion and cytoskeleton remodeling.


Modifications:
In compartment: Cytoplasm
  1. COL4A1@Cytoplasm map

Participates in complexes:
In compartment: Extracellular space

  1. COL4A1:​a2b1*_a3b1*@Extracellular space map

Participates in reactions:
As Reactant or Product:

  1. a2b1*_a3b1*@Extracellular space map + COL4A1@Cytoplasm map map COL4A1:​a2b1*_a3b1*@Extracellular space map

  2. Collagen4*@Extracellular space map map COL4A1@Cytoplasm map
  3. COL4A1:​a2b1*_a3b1*@Extracellular space map map Cell-matrix adhesions@Extracellular space map

As Catalyser:

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