CNA*:CNB*:ERK2*:MEK1*:NFAT*

Complex CNA*:CNB*:ERK2*:MEK1*:NFAT* map


Complex composition:

  1. CNA* map
  2. CNB* map
  3. ERK2* map
  4. MEK1* map
  5. NFAT* map




CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*|​pho@Nucleus

Identifiers
NAME:CNA*:CNB*:ERK2*:MEK1*:NFAT*

References
s_wnc3_re30( Survival  map ):
CnA binds to MEK1, MEK1 binds to ERK2 and ERK2 phosphorylates NFAT
PMID15657416
s_wnc3_re31( Survival  map ):
Phosphorylation of NFAT leads to increased DNA binding of NFAT -> increased gene transcription
Not sure if dissociation of calcineurin and ERK/MEK occurs
s_s_wnc3_re31( Survival  map ):

Confidence
REF=0 FUNC=2

CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*@Nucleus

Identifiers
NAME:CNA*:CNB*:ERK2*:MEK1*:NFAT*

References
s_wnc3_re29:( Survival  map ) PMID15657416
s_wnc3_re30( Survival  map ):
CnA binds to MEK1, MEK1 binds to ERK2 and ERK2 phosphorylates NFAT
PMID15657416

Confidence
REF=0 FUNC=2


Modifications:
Participates in complexes:
In compartment: Nucleus
  1. CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*@Nucleus map

  2. CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*|​pho@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. CNA*:​CNB*:​NFAT*@Nucleus map + ERK2*@Nucleus map + MEK1*@Nucleus map map CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*@Nucleus map

  2. CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*@Nucleus map map CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*|​pho@Nucleus map

As Catalyser:

  1. CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*|​pho@Nucleus map + gAP-1_ARRE binding sites*@Nucleus map + JUN@Nucleus map + FOS@Nucleus map map AP-1_ARRE binding sites*:​FOS:​JUN:​NFAT*@Nucleus map + CNA*:​CNB*@Nucleus map + ERK2*@Nucleus map + MEK1*@Nucleus map

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