CLSPN

Protein CLSPN map

Identifiers
Claspin
HUGO:CLSPN HGNC:19715 ENTREZ:63967 UNIPROT:Q9HAW4 GENECARDS:CLSPN REACTOME:171271 ATLASONC:CLSPNID40105ch1p34 WIKI:CLSPN
PMID:17303408, PMID:16880517, PMID:16934469

Maps_Modules
 DNA repair  map  / S_PHASE_CHECKPOINT  map
 DNA repair  map  / G2_M_CHECKPOINT  map

References
For S-phase checkpoint
PMID:15459660, PMID:19793801, PMID:17582221, PMID:18677104, PMID:17384638, PMID:12766152

CLSPN|​pho@default

References
d_re463( DNA repair  map ):
Arrests cell cycle in S-phase in response to stalled replication fork or ds breaks in DNA:
PMID:15459660, PMID:17384638, PMID:19793801


Modifications:
In compartment: default
  1. CLSPN@default map

  2. CLSPN|​pho@default map

Participates in complexes:
In compartment: default

  1. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​HCLK2*@default map

  2. ATRIP:​ATR|​pho:​CLSPN|​pho:​RAD17|​pho:​TOPBP1@default map
  3. ATRIP:​ATR|​pho:​CLSPN|​pho:​RPA1:​RPA2:​RPA3@default map
  4. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​PCNA|​K164_ubi:​TIM1*@default map
  5. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​RPA1:​RPA2:​RPA3:​TIM1*:​TIPIN@default map

Participates in reactions:
As Reactant or Product:

  1. TOPBP1@default map + ATRIP:​ATR|​pho@default map + CLSPN|​pho@default map + RAD17|​pho@default map map ATRIP:​ATR|​pho:​CLSPN|​pho:​RAD17|​pho:​TOPBP1@default map

  2. ATRIP:​ATR|​pho@default map + CLSPN|​pho@default map + RPA1:​RPA2:​RPA3@default map map ATRIP:​ATR|​pho:​CLSPN|​pho:​RPA1:​RPA2:​RPA3@default map
  3. HCLK2*@default map + CLSPN|​pho@default map + ATRIP:​ATR|​pho@default map + CHEK1|​pho|​active@default map map ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​HCLK2*@default map
  4. TIM1*@default map + CLSPN|​pho@default map + PCNA|​K164_ubi@default map + ATRIP:​ATR|​pho@default map + CHEK1|​pho|​active@Nucleus map map ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​PCNA|​K164_ubi:​TIM1*@default map
  5. CLSPN@default map map CLSPN|​pho@default map
  6. ATRIP:​ATR|​pho:​CLSPN|​pho:​RPA1:​RPA2:​RPA3@default map + TIPIN@default map + TIM1*@default map + CHEK1|​pho|​active@default map map ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​RPA1:​RPA2:​RPA3:​TIM1*:​TIPIN@default map

As Catalyser:

  1. S phase@default map map G2 phase@default map

  2. gDamaged_DNA*@Nucleus map map gRepaired_DNA*@Nucleus map
  3. CHEK1@default map map CHEK1|​pho|​active@default map
  4. ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*@default map + MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7@default map + CDT1@default map + CDC6@default map + CDC45@default map + POLA*@default map + PRIM*@default map + RPA1@Nucleus map + RPA2@Nucleus map + RPA3@Nucleus map map CDC45:​CDC6:​CDT1:​MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7:​ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*:​POLA*:​PRIM*:​RPA1:​RPA2:​RPA3@default map
  5. No DNA replicarion@default map map DNA replicarion@default map
  6. RAD1@default map + RAD9*|​pho@default map + HUS1@default map map HUS1:​RAD1:​RAD9*|​pho@default map
  7. HUS1:​RAD1:​RAD9*|​pho@default map + RAD17@default map + RFC*@Nucleus map map HUS1:​RAD1:​RAD17:​RAD9*:​RFC*@default map

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