cleaved~MCL1*

Protein cleaved~MCL1* map

Identifiers
myeloid cell leukemia sequence 1 (BCL2-related)
HUGO:MCL1 HGNC:6943 ENTREZ:4170 UNIPROT:Q07820 GENECARDS:MCL1 KEGG:4170 ATLASONC:GC_MCL1 WIKI:MCL1

Maps_Modules
 Apoptosis  map  / MOMP_REGULATION  map

References
whether CASP3- and GMZB-mediated cleavage products of MCL1 retain some anti-apoptotic activity or gain pro-apoptotic activity is a matter of debated
PMID:15713684

cleaved~MCL1*@Mitochondrial outer membrane

References
a_re42( Apoptosis  map ):
influenceDelete: reactants to re
we consider only that CASP3 or GZMB activity can influence Bax recruitment to membrane, not the fact that MCL1 increases it
hierarchical:post-MOMP
reactionType:proteases.cleavage
PMID:15713684
in different human cancer cell lines by Granzyme B
PMID:15637055
in Jurkat leukemia T cells, by CASP3 upon TRAIL-induced apoptosis
a_re29( Apoptosis  map ):
PMID:19968986
cleaved MCL1
PMID:14730312
ASC/PYCARD
PMID:19062087
in vitro in reconstituted liposomes, tBid is sufficient to induce Bax insertion into membrane and oligomerization


Modifications:
In compartment: Mitochondrial outer membrane
  1. cleaved~MCL1*@Mitochondrial outer membrane map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. MCL1|​S159_unk@Mitochondrial outer membrane map map cleaved~MCL1*@Mitochondrial outer membrane map

    As Catalyser:

    1. BAX@Cytoplasm map map BAX|​S163_unk|​T167_unk@Mitochondrial outer membrane map

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