cleaved~Caspase8*

Protein cleaved~Caspase8* map

Identifiers
caspase 8, apoptosis-related cysteine peptidase
HUGO:CASP8 HGNC:1509 ENTREZ:841 UNIPROT:Q14790 GENECARDS:CASP8 REACTOME:57032 KEGG:841 ATLASONC:GC_CASP8 WIKI:CASP8

Maps_Modules
 Apoptosis  map  / CASPASES  map
 Apoptosis  map  / MOMP_REGULATION  map
 Apoptosis  map  / TNF_RESPONSE  map

cleaved~Caspase8*@Cytoplasm

References
a_re691( Apoptosis  map ):
PMID:11788820
by HIP1:IFT57
a_re508( Apoptosis  map ):
PMID:9727492
in vitro cleavage of BID by CASP8 and GZMB, BID poor substrate for CASP3
in Jurkat cleavage of BID by CASP8 upon Fas stimulation
in Hela exposed to TNF+CHX cleavage of BID by CASP8
PMID:10805722
in vitro cleavage of in vitro translated BID by purified granzyme B
in Jurkat cells exposed to GZMB+adenovirus, BID cleavage occurs independently of caspases (zVAD-fmk)
PMID:11085743
in Jurkat cells exposed to GZMB+perforin, Bcl2 over-expression mediated cell protection is abrogated by over-over-expression of BID (wt or CASP8-uncleavable mutant) but of D75 (GZMB in vitro cleavage site) mutant
PMID:11085742
in Jurkat cells exposed to GZMB+adenovirus+zVAD-fmk, BID is cleaved and localizes to mitochondria
PMID:10364179
cleavage of BID by CASP8 and CASP3
PMID:11832478
in vitro by CASP2
a_re702:( Apoptosis  map ) PMID:12665579
a_re1234( Apoptosis  map ):
PMID:20125124
by HTRA2
PMID:10521396
by CASP8
PMID:19935698
by CASP2


Modifications:
In compartment: Cytoplasm
  1. cleaved~Caspase8*@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. Caspase8*@Cytoplasm map map cleaved~Caspase8*@Cytoplasm map

    2. cleaved~Caspase8*@Cytoplasm map map active~Caspases*@Cytoplasm map

    As Catalyser:

    1. RIPK1@TNFRSF1 Receptor Complex map map cleaved~RIPK1*@TNFRSF1 Receptor Complex map

    2. RIPK3@TNFRSF1 Receptor Complex map map cleaved~RIPK3*@TNFRSF1 Receptor Complex map
    3. BID@Cytoplasm map map cleaved_BID*@Cytoplasm map
    4. ABL1@Cytoplasm map map cleaved~ABL1*@Cytoplasm map

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