cleaved~Caspase3*

Protein cleaved~Caspase3* map

Identifiers
caspase 3, apoptosis-related cysteine peptidase
HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 GENECARDS:CASP3 REACTOME:57022 KEGG:836 ATLASONC:GC_CASP3 WIKI:CASP3

Maps_Modules
 Apoptosis  map  / AKT_MTOR  map
 Apoptosis  map  / CASPASES  map
 Apoptosis  map  / MITOCH_METABOLISM  map
 Apoptosis  map  / MOMP_REGULATION  map
 Apoptosis  map  / TNF_RESPONSE  map

cleaved~Caspase3*@Cytoplasm

References
a_re96( Apoptosis  map ):
PMID:10508159
CASP3 cleavage by cathepsin D as data not shown
a_re22( Apoptosis  map ):
hierarchical:post-MOMP
reactionType:casp.cleavage
PMID:12426317
zVAD-fmk inhibits YWHAQ and YWHAE but not YWHAZ cleavage and dissociation from BAX
PMID:15071501
putative cleavage sites in YWHAB, YWHAG, YWHAE, YWHAQ, SFN
absent in YWHAQ
PMID:12657644
YWHAE cleaved by CASP3
a_re42( Apoptosis  map ):
influenceDelete: reactants to re
we consider only that CASP3 or GZMB activity can influence Bax recruitment to membrane, not the fact that MCL1 increases it
reactionType:proteases.cleavage
PMID:15713684
in different human cancer cell lines by Granzyme B
PMID:15637055
in Jurkat leukemia T cells, by CASP3 upon TRAIL-induced apoptosis
a_re97( Apoptosis  map ):
PMID:8900201
a_re508( Apoptosis  map ):
PMID:9727492
in vitro cleavage of BID by CASP8 and GZMB, BID poor substrate for CASP3
in Jurkat cleavage of BID by CASP8 upon Fas stimulation
in Hela exposed to TNF+CHX cleavage of BID by CASP8
PMID:10805722
in vitro cleavage of in vitro translated BID by purified granzyme B
in Jurkat cells exposed to GZMB+adenovirus, BID cleavage occurs independently of caspases (zVAD-fmk)
PMID:11085743
in Jurkat cells exposed to GZMB+perforin, Bcl2 over-expression mediated cell protection is abrogated by over-over-expression of BID (wt or CASP8-uncleavable mutant) but of D75 (GZMB in vitro cleavage site) mutant
PMID:11085742
in Jurkat cells exposed to GZMB+adenovirus+zVAD-fmk, BID is cleaved and localizes to mitochondria
PMID:10364179
cleavage of BID by CASP8 and CASP3
PMID:11832478
in vitro by CASP2
a_re648( Apoptosis  map ):
PMID:11741536
in MCF7 upon TNF
in Hela upon TNF + CHX
a_re678:( Apoptosis  map ) reactionType:is.a
a_re687( Apoptosis  map ):
PMID:9108473
purification of DFFA:DFFB activity from Hela cells cytosol
in vitro, CASP3 mediated of DFFA necessary for nucleosomal DNA fragmentation
in U937 monocyte cells, in Hela cells, in SV589 human fibroblasts, upon staurosporin, DFFA cleaved into the same fragments as in vitro
PMID:9422506
purification and cloning of ICAD:CAD (mouse homologs) from mouse T-cell lymphoma cytosol
CASP3-mediated cleavage of ICAD releases CAD, leading to activation of its enzymatic activity and its nuclear localization
a_re1000( Apoptosis  map ):
PMID:10409669
CASP3 mediated cleavage of BCL2 in vitro and in HL60 cells or MCF7 with reconstituted CASP3 expression after exposure to staurosporine
no cleavage by CASP7
PMID:20139069
FKBP8 protects BCL2 from CASP3-mediated degradation
a_re1237( Apoptosis  map ):
PMID:10579725
PMID:12124386
in murine bone marrow IL3-dependent 32D cells, upon IL3 withdrawal
in vitro
a_re1241( Apoptosis  map ):
PMID:10454555
in HL60
a_re1247( Apoptosis  map ):
PMID:11106668
a_re1253( Apoptosis  map ):
PMID:12000740
in Jurkat upon anti FAS

cleaved~Caspase3*@Mitochondrial intermembrane space

References
a_re683:( Apoptosis  map ) PMID:15186778

cleaved~Caspase3*@Nucleus

References
a_re420( Apoptosis  map ):
hierarchical:post-MOMP
reactionType:casp.cleavage
PMID:19219071
a_re615( Apoptosis  map ):
PMID:12217801
in Jurkat, Fas induces HRK expression and DREAM:HRK-promoter dissociation (EMSA), which is blocked by z-VAD-fmk
in vitro, caspase 3 could cleave DREAM
a_re684( Apoptosis  map ):
PMID:9092486


Modifications:
In compartment: Cytoplasm
  1. cleaved~Caspase3*@Cytoplasm map

In compartment: Mitochondrial intermembrane space

  1. cleaved~Caspase3*@Mitochondrial intermembrane space map

In compartment: Nucleus

  1. cleaved~Caspase3*@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. cleaved~Caspase3*@Cytoplasm map map Caspase3_cl_uncl*@Cytoplasm map

    2. cleaved~Caspase3*@Cytoplasm map map cleaved~Caspase3*@Nucleus map
    3. cleaved~Caspase3*@Cytoplasm map map active~Caspases*@Cytoplasm map
    4. Caspase3*@Cytoplasm map map cleaved~Caspase3*@Cytoplasm map

    As Catalyser:

    1. BCL2|​unk@Mitochondrial outer membrane map map cleaved~BCL2*@Mitochondrial outer membrane map

    2. AKT1@Cytoplasm map map cleaved~AKT1*@Cytoplasm map
    3. ATM|​S1981_unk|​K3016_unk@Nucleus map map cleaved~ATM*@Site of DNA damage map
    4. BIRC2@Cytoplasm map map cleaved~BIRC2*@Cytoplasm map
    5. GCLC@Cytoplasm map map cleaved~GCLC*@Cytoplasm map
    6. 14-3-3*@Cytoplasm map map cleaved~14-3-3*@Cytoplasm map
    7. MCL1|​S159_unk@Mitochondrial outer membrane map map cleaved~MCL1*@Mitochondrial outer membrane map
    8. FUBP1@Nucleus map map cleaved_FUBP1*@Nucleus map
    9. BID@Cytoplasm map map cleaved_BID*@Cytoplasm map
    10. KCNIP3@Nucleus map map cleaved~KCNIP3*@Nucleus map
    11. IKK_beta_*@Cytoplasm map map cleaved~IKBKB*@Cytoplasm map
    12. FMN:​MT-ND1:​MT-ND2:​MT-ND3:​MT-ND4:​MT-ND4L:​MT-ND5:​MT-ND6:​NDUFA1:​NDUFA10:​NDUFA11:​NDUFA12:​NDUFA13:​NDUFA2:​NDUFA3:​NDUFA4:​NDUFA5:​NDUFA6:​NDUFA7:​NDUFA8:​NDUFA9:​NDUFAB1:​NDUFB1:​NDUFB10:​NDUFB11:​NDUFB2:​NDUFB3:​NDUFB4:​NDUFB5:​NDUFB6:​NDUFB7:​NDUFB8:​NDUFB9:​NDUFC1:​NDUFC2:​NDUFS1|​[2Fe-2S],[4Fe-4S],[4Fe-4S]:​NDUFS2:​NDUFS3:​NDUFS4:​NDUFS5:​NDUFS6:​NDUFS7|​[4Fe-4S]:​NDUFS8|​[4Fe-4S],[4Fe-4S]:​NDUFV1|​[4Fe-4S]:​NDUFV2|​[2Fe-2S]:​NDUFV3@Mitochondrial inner membrane map map cleaved~NDUFS1*@Mitochondrial intermembrane space map
    13. RB1@Nucleus map map cleaved_RB1*@Nucleus map
    14. DFFA:​DFFB@Cytoplasm map map DFFB@Cytoplasm map + cleaved~DFFA*@Cytoplasm map
    15. Caspase6*@Cytoplasm map map cleaved~Caspase6*@Cytoplasm map

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