cleaved~BCL2*

Protein cleaved~BCL2* map

Identifiers
B-cell CLL/lymphoma 2
HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 GENECARDS:BCL2 REACTOME:50758 KEGG:596 ATLASONC:BCL2ID49 WIKI:BCL2

Maps_Modules
 Apoptosis  map  / MOMP_REGULATION  map

cleaved~BCL2*@Mitochondrial outer membrane

References
a_re1000( Apoptosis  map ):
influenceDelete: reactants to re
hierarchical:post-MOMP
reactionType:casp.cleavage
PMID:10409669
CASP3 mediated cleavage of BCL2 in vitro and in HL60 cells or MCF7 with reconstituted CASP3 expression after exposure to staurosporine
no cleavage by CASP7
PMID:20139069
FKBP8 protects BCL2 from CASP3-mediated degradation
a_re14( Apoptosis  map ):
PMID:15486085
in FL5.12 cells correlation of BIM-BAX interaction in mitochondrial fractions with presence of unphosphorylated S65 BimEL
non phosphorylatable BimEL: enhanced interaction with BAX and enhanced proapoptotic activity
PMID:12419244
in vitro in reconstituted vesicles, BID induces BAX and membrane permeabilization


Modifications:
In compartment: Mitochondrial outer membrane
  1. cleaved~BCL2*@Mitochondrial outer membrane map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. BCL2|​unk@Mitochondrial outer membrane map map cleaved~BCL2*@Mitochondrial outer membrane map

    As Catalyser:

    1. BAX|​S163_unk|​T167_unk@Mitochondrial outer membrane map map a_s4588

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