cleaved_BID*

Protein cleaved_BID* map

Identifiers
BH3 interacting domain death agonist
HUGO:BID HGNC:1050 ENTREZ:637 UNIPROT:P55957 GENECARDS:BID REACTOME:50826 KEGG:637 ATLASONC:GC_BID WIKI:BID

Maps_Modules
 Apoptosis  map  / CASPASES  map
 Apoptosis  map  / MITOCH_METABOLISM  map
 Apoptosis  map  / MOMP_REGULATION  map

cleaved_BID*@Cytoplasm

References
a_re508( Apoptosis  map ):
PMID:9727492
in vitro cleavage of BID by CASP8 and GZMB, BID poor substrate for CASP3
in Jurkat cleavage of BID by CASP8 upon Fas stimulation
in Hela exposed to TNF+CHX cleavage of BID by CASP8
PMID:10805722
in vitro cleavage of in vitro translated BID by purified granzyme B
in Jurkat cells exposed to GZMB+adenovirus, BID cleavage occurs independently of caspases (zVAD-fmk)
PMID:11085743
in Jurkat cells exposed to GZMB+perforin, Bcl2 over-expression mediated cell protection is abrogated by over-over-expression of BID (wt or CASP8-uncleavable mutant) but of D75 (GZMB in vitro cleavage site) mutant
PMID:11085742
in Jurkat cells exposed to GZMB+adenovirus+zVAD-fmk, BID is cleaved and localizes to mitochondria
PMID:10364179
cleavage of BID by CASP8 and CASP3
PMID:11832478
in vitro by CASP2
a_re513( Apoptosis  map ):
PMID:11583622
in vitro, phosphorylation of BID has no effect on Granzyme B mediated cleavage
a_re514( Apoptosis  map ):
PMID:11940658
in vitro cleavage of BID by m-calpain
in human metastatic melanoma cell line, 224, in CASP3 deficient MCF-7 breast carcinoma cells, cleavage of BID by calpains and apoptosis in response to cisplatin
use of calpain inhibitors
involvment of mu-calpain cannot be ruled out
PMID:11404357
in rabbit heart mounted onto a Langendorff’s perfusion apparatus, upon ischemia/reperfusion, cleavage of BID by calpains
in vitro cleavage of BID by recombinant mu-calpain
PMID:17264306
in human neutrophils, upon bacteria-induced lysosomal permeabilization, BID cleavage and apoptosis are reversed by cathepsin but not caspase inhibition
PMID:18469004
in different human cell lines (HeLa, MCF-7, SH-SY5Y, HaCaT, CaCo-2,HepG2), upon LeuLeuOMe-induced lysosomal membrane permeabilisation, cleavage of Bid and apoptosis, rescued by E-64d cathepsin inhibitor
a_re515:( Apoptosis  map ) PMID:11099414

cleaved_BID*|​myr@Cytoplasm

References
a_re515:( Apoptosis  map ) PMID:11099414

cleaved_BID*|​myr@Mitochondrial outer membrane

References
a_re11( Apoptosis  map ):
PMID:10950869
direct activation of BAK by tBID
a_re14( Apoptosis  map ):
PMID:15486085
in FL5.12 cells correlation of BIM-BAX interaction in mitochondrial fractions with presence of unphosphorylated S65 BimEL
non phosphorylatable BimEL: enhanced interaction with BAX and enhanced proapoptotic activity
PMID:12419244
in vitro in reconstituted vesicles, BID induces BAX and membrane permeabilization
a_re29( Apoptosis  map ):
PMID:19968986
cleaved MCL1
PMID:14730312
ASC/PYCARD
PMID:19062087
in vitro in reconstituted liposomes, tBid is sufficient to induce Bax insertion into membrane and oligomerization


Modifications:
In compartment: Cytoplasm
  1. cleaved_BID*@Cytoplasm map

  2. cleaved_BID*|​myr@Cytoplasm map

In compartment: Mitochondrial outer membrane

  1. cleaved_BID*|​myr@Mitochondrial outer membrane map

Participates in complexes:
In compartment: Mitochondrial outer membrane

  1. BCL2:​cleaved_BID*|​myr@Mitochondrial outer membrane map

  2. BCL2A1:​cleaved_BID*|​myr@Mitochondrial outer membrane map
  3. BCL2L2:​cleaved_BID*|​myr@Mitochondrial outer membrane map
  4. BCL2-XL*:​cleaved_BID*|​myr@Mitochondrial outer membrane map
  5. MCL1|​S159_unk:​cleaved_BID*|​myr@Mitochondrial outer membrane map

Participates in reactions:
As Reactant or Product:

  1. BID@Cytoplasm map map cleaved_BID*@Cytoplasm map

  2. BID|​pho@Cytoplasm map map cleaved_BID*@Cytoplasm map
  3. BID|​unk@Cytoplasm map map cleaved_BID*@Cytoplasm map
  4. cleaved_BID*@Cytoplasm map map cleaved_BID*|​myr@Cytoplasm map
  5. cleaved_BID*|​myr@Cytoplasm map map cleaved_BID*|​myr@Mitochondrial outer membrane map
  6. cleaved_BID*|​myr@Mitochondrial outer membrane map + BCL2|​pho@Mitochondrial outer membrane map map BCL2:​cleaved_BID*|​myr@Mitochondrial outer membrane map
  7. cleaved_BID*|​myr@Mitochondrial outer membrane map + BCL2-XL*@Mitochondrial outer membrane map map BCL2-XL*:​cleaved_BID*|​myr@Mitochondrial outer membrane map
  8. cleaved_BID*|​myr@Mitochondrial outer membrane map + BCL2L2@Mitochondrial outer membrane map map BCL2L2:​cleaved_BID*|​myr@Mitochondrial outer membrane map
  9. cleaved_BID*|​myr@Mitochondrial outer membrane map + BCL2A1@Mitochondrial outer membrane map map BCL2A1:​cleaved_BID*|​myr@Mitochondrial outer membrane map
  10. cleaved_BID*|​myr@Mitochondrial outer membrane map + MCL1|​S159_unk@Mitochondrial outer membrane map map MCL1|​S159_unk:​cleaved_BID*|​myr@Mitochondrial outer membrane map

As Catalyser:

  1. BAK1@Mitochondrial outer membrane map map a_s11

  2. BAX|​S163_unk|​T167_unk@Mitochondrial outer membrane map map a_s4588
  3. BAX@Cytoplasm map map BAX|​S163_unk|​T167_unk@Mitochondrial outer membrane map

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