Claudin1_2_3_4*

Protein Claudin1_2_3_4* map

Identifiers
Claudin1_2_3_4*
claudin 1
HUGO:CLDN1 HGNC:2032 ENTREZ:9076 UNIPROT:O95832 GENECARDS:CLDN1 REACTOME:52232 KEGG:9076 ATLASONC:GC_CLDN1 WIKI:CLDN1
claudin 2
HUGO:CLDN2 HGNC:2041 ENTREZ:9075 UNIPROT:P57739 GENECARDS:CLDN2 REACTOME:52234 ATLASONC:GC_CLDN2 WIKI:CLDN2
Claudin 3
HUGO:CLDN3 HGNC:2045 ENTREZ:1365 UNIPROT:O15551 GENECARDS:CLDN3 REACTOME:52236 KEGG:1365 ATLASONC:GC_CLDN3 WIKI:CLDN3
Claudin 4
HUGO:CLDN4 HGNC:2046 ENTREZ:1364 UNIPROT:O14493 GENECARDS:CLDN4 REACTOME:52238 KEGG:1364 ATLASONC:CLDN4ID42975ch7q11 WIKI:CLDN4

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / TIGHT_JUNCTIONS  map

Claudin1_2_3_4*@Cytoplasm

References
e_re483( EMT  map ):
PMID:15070779
WNK4 binds and phosphorylates claudins 1–4.
Claudins 1–4 are known to be involved in the regulation of paracellular ion permeability.
The increases in phosphorylation of claudins were greater in cells expressing the mutant WNK4 than in cells expressing wild-type protein.
Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins.
So the phosphorylation of Claudins 1-4 by WNK4 involves in the regulation of paracellular ion permeability

Claudin1_2_3_4*|​pho@Cytoplasm

References
e_re483( EMT  map ):
PMID:15070779
WNK4 binds and phosphorylates claudins 1–4.
Claudins 1–4 are known to be involved in the regulation of paracellular ion permeability.
The increases in phosphorylation of claudins were greater in cells expressing the mutant WNK4 than in cells expressing wild-type protein.
Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins.
So the phosphorylation of Claudins 1-4 by WNK4 involves in the regulation of paracellular ion permeability


Modifications:
In compartment: Cytoplasm
  1. Claudin1_2_3_4*@Cytoplasm map

  2. Claudin1_2_3_4*|​pho@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. Claudin1_2_3_4*@Cytoplasm map + ATP@Cytoplasm map map Claudin1_2_3_4*|​pho@Cytoplasm map + ADP@Cytoplasm map

    2. Claudin1_2_3_4*@Cytoplasm map map Claudin1*@Cytoplasm map
    3. Claudin1_2_3_4*@Cytoplasm map map Claudin2*@Cytoplasm map
    4. Claudin1_2_3_4*@Cytoplasm map map Claudin3*@Cytoplasm map
    5. Claudin1_2_3_4*@Cytoplasm map map Claudin4*@Cytoplasm map

    As Catalyser:

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