e_re523( EMT ):
Snail binds directly to the E-boxes of the promoters of claudin et occludin genes, resulting in complete repression of their promoter activity
Snail and Slug bind to the E-box motifs present in the human Claudin-1 promoter.
High levels of Snail and Slug correlatedwith lowlevels of Claudin-1 expression.
It is proposed that Claudin-1 is a direct downstream target gene of Snail family factors in epithelial cells
The transcription factors B-catenin/Tcf complex has been shown to bind directly to the claudin-1 and claudin-2 promoters.
SNAI2 represses Claudin-1 expression
SNAI1 represses Claudin-1 expression
In compartment: Nucleus
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