CK1_epsilon_*:E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:p120*

Complex CK1_epsilon_*:E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:p120* map


Complex composition:

  1. LRP5_6* map
  2. E-Cadherin* map
  3. p120* map
  4. CK1_epsilon_* map
  5. PRR* map
  6. WNT* map
  7. FZD* map
  8. G_alpha_o* map
  9. G_beta_* map
  10. G_gamma_* map
  11. GTP map




CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​p120*@Vaceolae

Identifiers
NAME:CK1_epsilon_*:E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:p120*

Maps_Modules
 Survival  map  / WNT_CANONICAL  map

References
PMID:20940130 PMID:21606194
s_wca1_re25:( Survival  map ) PMID:21606194 PMID:19705439
s_wca1_re28( Survival  map ):
PMID:20006983 PMID:16965538 PMID:210606194 PMID:20093472 PMID:21796133
Phosphorylation of DVL by CK1 epsilon. Activation of CK1 epsilon by unknown factor
An acidic environment is required for phosphorylation of DVL and LRP5/6
s_wca1_re51( Survival  map ):
PMID:16547521
In the presence of WNT3a DVL-3 forms complex with KLHL12/CUL3/RBX1-complex
s_wca1_re57( Survival  map ):
PMID:19718039 PMID:21602792
In presence of WNT ligand
s_wca1_re68( Survival  map ):
PMID:20093472
PRR binds to subunits ATP6V0C and D those are subunits of the V-ATPase.

Confidence
REF=5 FUNC=3


Modifications:
Participates in complexes:
In compartment: Vaceolae
  1. CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​p120*@Vaceolae map

Participates in reactions:
As Reactant or Product:

  1. WNT*@default map + CK1_epsilon_*:​E-Cadherin*:​LRP5_6*:​p120*@Vaceolae map + s_s_wca1_s211 + GTP@Vaceolae map + PRR*@Cytoplasm map map CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​p120*@Vaceolae map + GDP@Vaceolae map

  2. DVL*|​pho|​S139_emp|​S142_emp:​_beta_-Arrestin2*@Cytoplasm map + CK1_epsilon_*:​E-Cadherin*:​FZD*:​GTP:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​p120*@Vaceolae map + AMER1*:​CK1_gamma_*:​PtdIns(4,5)-P2@Cytoplasm map map AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​S139_pho|​S142_pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae map + s_s_wca1_s1187 + G_beta_*:​G_gamma_*@Cytoplasm map

As Catalyser:

  1. DVL*@Cytoplasm map + s_s_wca1_s725 map DVL*:​KLHL*@Cytoplasm map

  2. s_s_wca1_s758 map JBN*:​_beta_-Catenin*@Cilium map
  3. JBN*:​_beta_-Catenin*@Cilium map map s_s_wca1_s764
  4. ATP6V0C_D*@Vaceolae map map ATP6V0C_D*@Vaceolae map

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