CK1_epsilon_*:CTHRC1:DVL*:PRICKLE1:PRR*:ROR2:SYN4*:VANGL*:_beta_-Arrestin2*

Complex CK1_epsilon_*:CTHRC1:DVL*:PRICKLE1:PRR*:ROR2:SYN4*:VANGL*:_beta_-Arrestin2* map


Complex composition:

  1. ROR2 map
  2. CK1_epsilon_* map
  3. CTHRC1 map
  4. SYN4* map
  5. _beta_-Arrestin2* map
  6. VANGL* map
  7. PRICKLE1 map
  8. DVL* map
  9. PRR* map




CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm

Identifiers
NAME:CK1_epsilon_*:CTHRC1:DVL*:PRICKLE1:PRR*:ROR2:SYN4*:VANGL*:_beta_-Arrestin2*

References
PCP MODULE
s_wnc1_re66( Survival  map ):
Polymerisation of Dvl-proteins is not associated with endosomes or other vesicles. Polymerization of Dvl acts as scaffold for recruiting Rac1
PMID:20457807
s_wnc1_re86:( Survival  map ) PMID:17030191
s_wnc1_re88( Survival  map ):
Smurf associates upon binding of Wnt5 to frizzled
PMID:19379695

Confidence
REF=3 FUNC=2

CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm

Identifiers
NAME:CK1_epsilon_*:CTHRC1:DVL*:PRICKLE1:PRR*:ROR2:SYN4*:VANGL*:_beta_-Arrestin2*

References
PCP MODULE
s_wnc1_re88( Survival  map ):
Smurf associates upon binding of Wnt5 to frizzled
PMID:19379695
s_wnc1_re89( Survival  map ):
Ubiquitination of Prickle by Smurf
PMID:20930545
s_s_wnc1_re89( Survival  map ):

Confidence
REF=1 FUNC=2

CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho|​ubi:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm

Identifiers
NAME:CK1_epsilon_*:CTHRC1:DVL*:PRICKLE1:PRR*:ROR2:SYN4*:VANGL*:_beta_-Arrestin2*

References
PCP MODULE
s_wnc1_re89( Survival  map ):
Ubiquitination of Prickle by Smurf
PMID:19379695
PMID:20930545
s_wnc1_re111( Survival  map ):
Rspo is required for clathrin-mediated endocytosis
PMID:21397842
It has been shown that Dvl polymers are not associated with vesicles, therefore endocytosis of the complex is likely to be after Dvl polymerisation.
PMID:16263762

Confidence
REF=3 FUNC=2


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map

  2. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map
  3. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho|​ubi:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho|​ubi:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map + RSPO3@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRR*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map + SMURF1@Cytoplasm map + PRICKLE1|​pho|​ubi@Cytoplasm map

  2. CK1_epsilon_*:​CTHRC1:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*@Cytoplasm map + DVL*|​pho|​emp|​emp:​_beta_-Arrestin2*@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map
  3. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​ROR2|​S864_emp|​emp|​emp:​SYN4*:​VANGL*|​emp|​emp|​emp|​emp:​_beta_-Arrestin2*@Cytoplasm map
  4. SMURF1@Cytoplasm map + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map
  5. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho|​ubi:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map

As Catalyser:

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